Journal ArticleDOI
Long-term efficacy and safety of modafinil (PROVIGIL®) for the treatment of excessive daytime sleepiness associated with narcolepsy
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TLDR
Modafinil is effective for the long-term treatment of EDS associated with narcolepsy and significantly improves perceptions of general health, with no evidence of tolerance developing during 40 weeks of treatment.About:
This article is published in Sleep Medicine.The article was published on 2000-07-01. It has received 129 citations till now. The article focuses on the topics: Modafinil & Excessive daytime sleepiness.read more
Citations
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Journal ArticleDOI
Modafinil: A Review of Neurochemical Actions and Effects on Cognition
TL;DR: Overall, modafinil is an excellent candidate agent for remediation of cognitive dysfunction in neuropsychiatric disorders and shows initial promise for a variety of off-label indications in psychiatry.
Journal ArticleDOI
Efficacy and safety of modafinil (Provigil ® ) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study
Kottil Rammohan,J H Rosenberg,D J Lynn,Andrew M. Blumenfeld,Charles P. Pollak,Haikady N. Nagaraja +5 more
TL;DR: Data suggest that 200 mg/day modafinil significantly improves fatigue and is well tolerated in patients with MS.
Journal ArticleDOI
A systematic review of modafinil: Potential clinical uses and mechanisms of action.
Jacob S. Ballon,David Feifel +1 more
TL;DR: The strongest evidence among off-label uses exists for the use of modafinil in attention-deficit disorder, postanesthetic sedation, and cocaine dependence and withdrawal and as an adjunct to antidepressants for depression.
Journal ArticleDOI
What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Benjamin Boutrel,George F. Koob +1 more
TL;DR: Understanding the exact role of the hypocretin/orexin and dopamine systems in the physiology and pharmacology of sleep-wake regulation may reveal new insights into current and future wakefulness-promoting drugs.
Journal ArticleDOI
Modafinil as Adjunct Therapy for Daytime Sleepiness in Obstructive Sleep Apnea
TL;DR: Modafinil may be a useful adjunct treatment for the management of residual daytime sleepiness in patients with obstructive sleep apnea/hypopnea syndrome who are regular users of nasal continuous positive airway pressure therapy.
References
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Journal ArticleDOI
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
Book
SF-36 health survey: Manual and interpretation guide
TL;DR: TheSF-36 is a generic health status measure which has gained popularity as a measure of outcome in a wide variety of patient groups and social and the contribution of baseline health, sociodemographic and work-related factors to the SF-36 Health Survey: manual and interpretation guide is tested.
Journal ArticleDOI
The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.
TL;DR: In this article, cross-sectional data from the Medical Outcomes Study (MOS) were analyzed to test the validity of the MOS 36-Item Short-Form Health Survey (SF-36) scales as measures of physical and mental health constructs.
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Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy
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