Long‐term follow‐up of febrile infection–related epilepsy syndrome
Katherine B. Howell,Kamornwan Katanyuwong,Mark T Mackay,Catherine A Bailey,Ingrid E. Scheffer,Jeremy L. Freeman,Samuel F. Berkovic,A. Simon Harvey +7 more
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TLDR
The features of the chronic epilepsy are described and critically review evidence for the etiology of this syndrome is critically reviewed.Citations
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New-onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectives
Nicolas Gaspard,Nicolas Gaspard,Lawrence J. Hirsch,Claudine Sculier,Claudine Sculier,Tobias Loddenkemper,Andreas van Baalen,Judette Lancrenon,Michel Emmery,Nicola Specchio,Raquel Farias-Moeller,Nora Wong,Rima Nabbout +12 more
TL;DR: The strategy to unravel the cause of these disorders and to improve patient care is presented and standardized consensus definitions and a multidisciplinary multicenter strategy are presented to improve clinical care for patients with NORSE and FIRES.
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Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases.
Jacqueline S. Gofshteyn,Angus Wilfong,Orrin Devinsky,Judith Bluvstein,Joshi Charuta,Michael A. Ciliberto,Linda Laux,Eric D. Marsh,Eric D. Marsh +8 more
TL;DR: Cannabidiol is added as a possible treatment for febrile infection-related epilepsy syndrome who had not responded to antiepileptic drugs or other therapies who were given cannabadiol on emergency or expanded investigational protocols in either the acute or chronic phase of illness.
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Febrile Infection-Related Epilepsy Syndrome: Clinical Review and Hypotheses of Epileptogenesis.
TL;DR: It is hypothesized that FIRES is an immune but not an autoimmune disease and discussed GABAergic therapy at high doses, avoidance of burst-suppression coma, and early introduction of enteral or even parenteral ketogenic diet as the most promising treatment.
Journal ArticleDOI
New onset refractory status epilepticus (NORSE).
TL;DR: This review presents the rare but devastating syndrome of NORSE, including the subcategory of FIRES, and suggests early recognition with complete work-up is primordial to identify the underlying cause and promptly start appropriate treatment.
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Functional deficiency in endogenous interleukin‐1 receptor antagonist in patients with febrile infection‐related epilepsy syndrome
Benjamin D. S. Clarkson,Reghann G. LaFrance-Corey,Robert J. Kahoud,Raquel Farias-Moeller,Eric T. Payne,Charles L. Howe +5 more
TL;DR: It is shown that treatment with the recombinant interleukin‐1 (IL1) receptor antagonist anakinra results in down-regulation in the production and function of endogenous IL1RA in patients with FIRES.
References
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Revised Terminology and Concepts for Organization of Seizures and Epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009
Anne T. Berg,Anne T. Berg,Samuel F. Berkovic,Martin J. Brodie,Jeffrey Buchhalter,J. Helen Cross,Walter van Emde Boas,Jerome Engel,Jacqueline A. French,Tracy A. Glauser,Gary W. Mathern,Solomon L. Moshé,Douglas R. Nordli,Perrine Plouin,Ingrid E. Scheffer +14 more
TL;DR: The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy.
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Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.
Jonathan C. W. Edwards,Leszek Szczepanski,Jacek Szechiński,Anna Filipowicz-Sosnowska,Paul Emery,D. Close,Randall M Stevens,T. Shaw +7 more
TL;DR: In patients with active rheumatoid arthritis despite methotrexate treatment, a single course of two infusions of rituximab, alone or in combination with either cyclophosphamide or continued methotRexate, provided significant improvement in disease symptoms at both weeks 24 and 48.
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Defining criteria for autoimmune diseases (Witebsky's postulates revisited)
Noel R. Rose,Constantin A. Bona +1 more
TL;DR: In this article, three types of evidence can be marshalled to establish that a human disease is autoimmune in origin: direct evidence from transfer of pathogenic antibody or pathogenic T cells; indirect evidence based on reproduction of the autoimmune disease in experimental animals; and circumstantial evidence from clinical clues.
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Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation
Ikuo Ogiwara,Hiroyuki Miyamoto,Noriyuki Morita,Nafiseh Atapour,Emi Mazaki,Ikuyo Inoue,T. Takeuchi,Shigeyoshi Itohara,Yuchio Yanagawa,Kunihiko Obata,Teiichi Furuichi,Takao K. Hensch,Kazuhiro Yamakawa +12 more
TL;DR: The authors' data indicate that Nav1.1 plays critical roles in the spike output from PV interneurons and, furthermore, that the specifically altered function of these inhibitory circuits may contribute to epileptic seizures in the mice.
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An open label study of the effects of rituximab in neuromyelitis optica
TL;DR: Eight patients with worsening neuromyelitis optica were treated with rituximab to achieve B cell depletion and seven of eight patients experienced substantial recovery of neurologic function over 1 year of average follow-up.