Long-Term Mortality after Recombinant Growth Hormone Treatment for Isolated Growth Hormone Deficiency or Childhood Short Stature: Preliminary Report of the French SAGhE Study
Jean-Claude Carel,Emmanuel Ecosse,Fabienne Landier,Djamila Meguellati-Hakkas,Florentia Kaguelidou,Grégoire Rey,Joël Coste +6 more
TLDR
Mortality rates were increased in this population of adults treated as children with recombinant GH, particularly in those who had received the highest doses, highlighting the need for additional studies of long-term mortality and morbidity after GH treatment in childhood.Abstract:
Context: Little is known about the long-term health of subjects treated with GH in childhood, and Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) is a study addressing this question. Objective: The objective of the study was to evaluate the long-term mortality of patients treated with recombinant GH in childhood in France. Design: This was a population-based cohort study. Setting: The setting of the study was a French population-based register. Participants: A total of 6928 children with idiopathic isolated GH deficiency (n = 5162), neurosecretory dysfunction (n = 534), idiopathic short stature (n = 871), or born short for gestational age (n = 335) who started treatment between 1985 and 1996 participated in the study. Follow-up data on vital status were available in September 2009 for 94.7% of the patients. Main outcome measures: All-cause and cause-specific mortality was measured in the study. Results: All-cause mortality was increased in treated subjects [standardized mortality...read more
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Multiple Imputation for Nonresponse in Surveys
TL;DR: It is concluded that multiple Imputation for Nonresponse in Surveys should be considered as a legitimate method for answering the question of why people do not respond to survey questions.
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Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Adda Grimberg,Sara A. DiVall,Constantin Polychronakos,David B. Allen,Laurie E. Cohen,Jose Bernardo Quintos,Wilma C. Rossi,Chris Feudtner,Mohammad Hassan Murad +8 more
TL;DR: This guideline provides recommendations for the clinical management of children and adolescents with growth failure from GHD, ISS, or PIGFD using the best available evidence.
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Growth hormone research society workshop summary: Consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome
Cheri Deal,Michele Tony,Charlotte Höybye,David B. Allen,Maithé Tauber,Jens Sandahl Christiansen,Geoffrey R Ambler,Renaldo N. Battista,Véronique Beauloye,Glenn Berall,Beverly M. K. Biller,Merlin G. Butler,Suzanne B. Cassidy,Kazuo Chihara,Pinchas Cohen,Maria E. Craig,Stense Farholt,Mireille M Goetghebeur,Anthony P. Goldstone,Tiziana Greggi,Graziano Grugni,Anita C. S. Hokken-Koelega,Gudmundur Johannsson,Keegan Johnson,Alex R. Kemper,John J. Kopchick,Saul Malozowski,Jennifer L. Miller,Harriette R. Mogul,Françoise Muscatelli,Ricard Nergårdh,Robert D. Nicholls,Sally Radovick,M. Sara Rosenthal,Ilkka Sipilä,Jean-Eric Tarride,Annick Vogels,Michael J. Waters +37 more
TL;DR: Following a multidisciplinary evaluation, preferably by experts, rhGH treatment should be considered for patients with genetically confirmed PWS in conjunction with dietary, environmental, and lifestyle interventions.
Journal ArticleDOI
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis.
TL;DR: GH administration for the treatment of osteoporosis and bone fractures may greatly improve clinical outcome and both GH and IGF-1 therapy has a significant anabolic effect.
Journal ArticleDOI
Long-Term Mortality and Causes of Death in Isolated GHD, ISS, and SGA Patients Treated with Recombinant Growth Hormone during Childhood in Belgium, The Netherlands, and Sweden: Preliminary Report of 3 Countries Participating in the EU SAGhE Study
Lars Sävendahl,Marc Maes,Kerstin Albertsson-Wikland,Birgit Borgström,Jean-Claude Carel,Séverine Henrard,Niko Speybroeck,Muriel Thomas,Gladys R J Zandwijken,Anita C. S. Hokken-Koelega +9 more
TL;DR: Preliminary data on long-term vital status and causes of death in patients with isolated GH deficiency or idiopathic short stature or born small for gestational age treated with GH during childhood, in Belgium, The Netherlands, and Sweden are reported.
References
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Multiple imputation for nonresponse in surveys
TL;DR: In this article, a survey of drinking behavior among men of retirement age was conducted and the results showed that the majority of the participants reported that they did not receive any benefits from the Social Security Administration.
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TL;DR: Statistical methods in cancer research as mentioned in this paper, Statistical Methods in Cancer Research, Statistical methods in Cancer research, Statistical methods for cancer research, کتابخانه مرکزی دانشگاه علوم پزش
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Statistical methods in cancer research
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Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: What do you do to start reading statistical methods in cancer research vol ii the design and analysis of cohort studies?
Journal ArticleDOI
Multiple Imputation for Nonresponse in Surveys
TL;DR: It is concluded that multiple Imputation for Nonresponse in Surveys should be considered as a legitimate method for answering the question of why people do not respond to survey questions.