Journal ArticleDOI
Long-term triphenyltin exposure disrupts adrenal function in adult male rats.
TLDR
Triphenyltin disrupts glucocorticoid synthesis in rat adrenal cortex via several mechanisms: 1) lowering AKT1 phosphorylation and SIRT1/PGC-1α levels; 2) activating AMPKα; and 3) possibly inducing ROS production.About:
This article is published in Chemosphere.The article was published on 2020-03-01. It has received 9 citations till now. The article focuses on the topics: Zona fasciculata & Zona glomerulosa.read more
Citations
More filters
Journal ArticleDOI
Review on endocrine disrupting toxicity of triphenyltin from the perspective of species evolution: Aquatic, amphibious and mammalian.
Shuwen He,Ping Li,Zhi-Hua Li +2 more
TL;DR: TP should indeed be regarded as a major endocrine disruptor, which is essential for understanding the main toxic effects on different tissues and their pathogenic effects on endocrine, metabolism, neurological and reproductive dysfunction.
Journal ArticleDOI
Triphenyltin disrupts the testicular microenvironment and reduces sperm quality in adult male rats.
Mengxi Lu,Yan Mu,Yi Li +2 more
TL;DR: In this paper , the effects of Triphenyltin (TPT) on the testicular microenvironment and sperm quality in male rats were investigated, and the results showed that TPT dose-dependently decreased sperm count and sperm motility, interfered with sperm histone-protamine replacement process, and significantly increased sperm deformity rate, but did not affect sperm DNA integrity.
Journal ArticleDOI
Triphenyltin chloride reduces the development of rat adrenal cortex during puberty
Xingwang Li,Linchao Li,Xiuxiu Chen,Xiaoheng Li,Yiyan Wang,Qiqi Zhu,Fang Gao-Smith,Ren-Shan Ge +7 more
TL;DR: Triphenyltin inhibits production of corticosterone via blocking the expression of cholesterol uptake transporters and cholesterol biosynthesis through dose-dependently down-regulation of the genes for cholesterol transport and biosynthesis.
Journal ArticleDOI
Toxic effects of triphenyltin on the silkworm Bombyx mori as a lepidopterous insect model.
TL;DR: In this article , the authors investigated the toxicity of Triphenyltin (TPT) in the silkworm Bombyx mori as a model insect and found that TPT exposure for the entire 5th instar larval stage significantly reduced the weight of silkworm pupa and inhibited development of the midgut.
Journal ArticleDOI
Effects of bis (2‐butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down‐regulating NR5A1/NR4A1/NR4A2 pathways
Miaoqing Liu,Haiqiong Chen,Haipeng Dai,Yang Wang,Jingjing Li,Fuhong Tian,Zhongrong Li,Ren-Shan Ge +7 more
TL;DR: Male rats exposed to BBOP in puberty have significant reduction of steroid biosynthesis with a potential mechanism that is involved in the decrease in the phosphorylation of AKT1, AKT2, ERK1/2, as well as SIRT1 and PGC1α and increase in ROS.
References
More filters
Journal ArticleDOI
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
TL;DR: The analysis of two SIR2 mutations supports the idea that this deacetylase activity accounts for silencing, recombination suppression and extension of life span in vivo, and provides a molecular framework of NAD-dependent histone de acetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes.
Journal ArticleDOI
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
TL;DR: Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes.
Journal ArticleDOI
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Mary-Elizabeth Patti,Atul J. Butte,Sarah Crunkhorn,Kenneth Cusi,Rachele Berria,Sangeeta R. Kashyap,Yoshinori Miyazaki,Isaac S. Kohane,Maura Costello,Robert Saccone,Edwin J. Landaker,Allison B. Goldfine,Edward C. Mun,Ralph A. DeFronzo,Jean Finlayson,C. Ronald Kahn,Lawrence J. Mandarino +16 more
TL;DR: It is demonstrated that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 (NRF-1)-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function.
Journal ArticleDOI
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure.
Carles Cantó,Johan Auwerx +1 more
TL;DR: Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master regulator of mitochondria, PGC-1α, are vital links in a regulatory network for metabolic homeostasis and understanding the mechanisms by which they act could guide us to identify and improve preventive and therapeutic strategies for metabolic diseases.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.