Journal ArticleDOI
Loss of GABAergic neurons in medial septum after fimbria-fornix transection.
TLDR
It is reported here that GABAergic neurons are indeed lost after the transection but the time course is considerably slower than that for the cholinergic neurons.About:
This article is published in Neuroscience Letters.The article was published on 1987-05-06. It has received 93 citations till now. The article focuses on the topics: Cholinergic neuron & GABAergic.read more
Citations
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Journal ArticleDOI
Do septal neurons pace the hippocampal theta rhythm
Mark G. Stewart,S. E. Fox +1 more
TL;DR: Four models of the septo-hippocampal connections involved in theta rhythm production are reviewed as the precise roles of these projections are discussed, and in the final, consolidated model both cholinergic and GABAergic septal projection cells fire in rhythmic bursts that entrain hippocampal interneurons.
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Morphological response of axotomized septal neurons to nerve growth factor.
TL;DR: Qualitative morphometric techniques evaluated the response of axotomized septal neurons to a constant infusion of nerve growth factor (NGF) and saved neurons had the same parameters as the undamaged ChAT‐IR neurons when examined in either 40‐μm‐ or 1‐ μm‐thick sections.
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Basic fibroblast growth factor and nerve growth factor administered in gel foam rescue medial septal neurons after fimbria fornix transection.
TL;DR: The results suggest a possible role for FGF as a neurotrophic factor for CNS neurons in vivo and reveal dramatic losses of cholinergic neurons on the lesioned, compared with the unlesioned, side.
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Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS.
TL;DR: Recombinant human ciliary neurotrophic factor was infused into the lateral ventricle of fimbria-fornix transected adult rats, and its effects were compared with those of purified mouse nerve growth factor (NGF).
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The extrinsic modulation of hippocampal theta depends on the coactivation of cholinergic and GABA-ergic medial septal inputs.
TL;DR: It is proposed that cholinergic and GABA-ergic systems originating in the MS/vDBB act synergistically to modulate hippocampal theta, which may determine whether hippocampal synchrony (theta) or asynchrony (LIA) occurs.
References
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Journal ArticleDOI
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
TL;DR: It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
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Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
TL;DR: It was difficult to identify substance-P immunoreactive axons in the rats studied, and further experimental studies are necessary to elucidate the projections of the substance P-immunoreactive neurons in the rat central nervous system.
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Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
Lawrence R. Williams,Silvio Varon,Gary M. Peterson,Klas Wictorin,Walter Fischer,Anders Björklund,Fred H. Gage +6 more
TL;DR: It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.
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An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat
David G. Amaral,J. Kurz +1 more
TL;DR: Injections of WGA‐HRP were placed into different regions of the hippocampal formation and sections through the septal complex were processed for the simultaneous demonstration of the retrogradely transported marker and for choline acetyltransferase (ChAT) immunoreactivity.
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Septal neurons containing glutamic acid decarboxylase immunoreactivity project to the hippocampal region in the rat brain.
TL;DR: Findings provide evidence that a significant portion of the septohippocampal projection may utilize gamma-aminobutyric acid as a neurotransmitter.