Journal ArticleDOI
Lung Cancer: Posttreatment Imaging: Radiation Therapy and Imaging Findings.
Marcelo F. Benveniste,Daniel R. Gomez,Chitra Viswanathan,Girish S. Shroff,Sonia L. Betancourt Cuellar,Brett W. Carter,Edith M. Marom,Edith M. Marom +7 more
TLDR
Over the last few decades, advances in radiation therapy technology have markedly improved radiation delivery, allow precise delivery of high doses of radiation conformed to the tumor, and result in improved locoregional control while reducing radiation dose to surrounding normal tissue.Abstract:
Over the last few decades, advances in radiation therapy technology have markedly improved radiation delivery. Advancements in treatment planning with the development of image-guided radiotherapy and techniques such as proton therapy, allow precise delivery of high doses of radiation conformed to the tumor. These advancements result in improved locoregional control while reducing radiation dose to surrounding normal tissue. The radiologic manifestations of these techniques can differ from radiation induced lung disease seen with traditional radiation therapy. Awareness of these radiologic manifestations and correlation with radiation treatment plans are important to differentiate expected radiation induced lung injury from recurrence, infection and drug toxicity.read more
Citations
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Radiation-Induced Lung Injury: Assessment and Management.
TL;DR: Current research advances include high-precision radiation techniques, an improved understanding of the molecular basis of RILI, the development of small and large animal models, and the identification of candidate drugs for prevention and treatment.
Journal ArticleDOI
Early and Late Lung Injury Following Stereotactic Radiation Therapy
Journal Article
Radiation Injury of the Lung After Stereotactic Body Radiation Therapy (SBRT) for Lung Cancer. CT and PET/CT Imaging.
TL;DR: Stereotactic body-radiation therapy (SBRT) is an effective treatment with excellent results for patients with peripheral stage I non-small-cell lung cancer that is inoperable as discussed by the authors.
Journal ArticleDOI
Paradigm Shift in Lung Cancer Therapy: Imaging and Clinical Implications
TL;DR: This symposium on the imaging and clinical implications of lung cancer therapy offers an in-depth review of the imaging of targeted therapy, immunotherapy, radiation therapy,3 and surgical complications.
References
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Journal ArticleDOI
A new international staging system for lung cancer
TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
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Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study
Jeffrey D. Bradley,Rebecca Paulus,Ritsuko Komaki,Gregory A. Masters,George R. Blumenschein,Steven E. Schild,Jeffrey A. Bogart,Chen Hu,Kenneth M. Forster,Anthony M. Magliocco,V.S. Kavadi,Yolanda I. Garces,Samir Narayan,Puneeth Iyengar,Cliff G. Robinson,Raymond B. Wynn,Christopher Koprowski,Joanne Meng,Jonathan J. Beitler,Rakesh Gaur,Walter J. Curran,Hak Choy +21 more
TL;DR: Overall survival after standard-dose versus high-dose conformal radiotherapy with concurrent chemotherapy and the addition of cetuximab to concurrent chemoradiation for patients with inoperable stage III non-small-cell lung cancer was compared.
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A meta-analysis of thoracic radiotherapy for small-cell lung cancer.
Jean Pierre Pignon,Rodrigo Arriagada,Daniel C. Ihde,David H. Johnson,Michael C. Perry,Robert L. Souhami,Ola Brodin,Rudolf A. Joss,Merrill S. Kies,Bernard Lebeau,Taisuke Onoshi,Kell Østerlind,Martin H.N. Tattersall,Henry Wagner +13 more
TL;DR: Thoracic radiotherapy moderately improves survival in patients with limited small-cell lung cancer who are treated with combination chemotherapy, and identification of the optimal combination of chemotherapy and radiotherapy will require further trials.
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Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.
Hiroshi Onishi,Hiroki Shirato,Yasushi Nagata,Masahiro Hiraoka,Masaharu Fujino,Kotaro Gomi,Yuzuru Niibe,Katsuyuki Karasawa,Kazushige Hayakawa,Yoshihiro Takai,Tomoki Kimura,A. Takeda,Atsushi Ouchi,Masato Hareyama,Masaki Kokubo,Ryusuke Hara,Jun Itami,Kazunari Yamada,Tsutomu Araki +18 more
TL;DR: HypoFXSRT with a BED of less than 180 Gy was almost safe for stage I NSCLC, and the local control and overall survival rates in 5 years with a AED of 100 Gy or more were superior to the reported results for conventional radiotherapy.
Journal ArticleDOI
Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis.
Padraig Warde,David G. Payne +1 more
TL;DR: This meta-analysis shows a small but significant improvement in survival and a major improvement in tumor control in the thorax in patients receiving thoracic radiation therapy, but this is achieved at the cost of a small increase in treatment-related mortality.