Journal ArticleDOI
Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data.
Sana Maher Hasan Aghbari,Abdelrahman Ibrahim Abushouk,Attia O. Attia,Ahmed Elmaraezy,Amr Menshawy,Mohamed Shehata Ahmed,Basma Elsaadany,Eman Ahmed +7 more
TLDR
A higher incidence of malignant transformation was found among smokers, alcoholics, and HCV-infected patients; however, these associations should be further investigated.About:
This article is published in Oral Oncology.The article was published on 2017-05-01. It has received 190 citations till now. The article focuses on the topics: Oral lichen planus.read more
Citations
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Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes.
TL;DR: The joint differential miRNA expression and survival analysis controlling for multiple confounding covariates implemented in this study allowed for the identification of a previously undetected prognostic miRNA signature characteristic of a broad range of HNSCC.
Journal ArticleDOI
Oral cancer development in lichen planus and related conditions-3.0 evidence level: A systematic review of systematic reviews.
TL;DR: In this paper, a systematic review of systematic reviews and meta-analyses is presented on cancer development in oral lichen planus (OLP), OLL, and OLL reactions (OLR).
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Malignant transformation of oral submucous fibrosis: A systematic review and meta-analysis.
TL;DR: It is confirmed that close to 4% of patients diagnosed with OSF may develop oral cancer, and the demographic and clinicopathological factors contributing to the progression of OSF to cancer are evaluated.
Journal ArticleDOI
Oral lichenoid dysplasia and not oral lichen planus undergoes malignant transformation at high rates.
TL;DR: Compared with other oralLichenoid conditions, OLD lesions are at a particularly high risk of malignant transformation and should be managed based on the presence of dysplasia and not the lichenoid inflammatory infiltrate.
Journal ArticleDOI
Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection (Review)
Simona Roxana Georgescu,Mircea Tampa,Mădălina Irina Mitran,Cristina Iulia Mitran,Maria Isabela Sarbu,Ilinca Nicolae,Clara Matei,Constantin Caruntu,Monica Neagu,Mircea Ioan Popa +9 more
TL;DR: The aim of this review is to summarize the main potential mechanisms involved in the association between LP and HCV infection and shed some light on the pathogenesis of LP, which is a challenging issue.
References
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
TL;DR: The quality assessment of non-randomized studies is an important component of a thorough meta-analysis of non randomized studies and can dramatically influence the interpretation of meta-analyses, and can even reverse conclusions regarding the effectiveness of an intervention.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.