Journal ArticleDOI
Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data.
Sana Maher Hasan Aghbari,Abdelrahman Ibrahim Abushouk,Attia O. Attia,Ahmed Elmaraezy,Amr Menshawy,Mohamed Shehata Ahmed,Basma Elsaadany,Eman Ahmed +7 more
TLDR
A higher incidence of malignant transformation was found among smokers, alcoholics, and HCV-infected patients; however, these associations should be further investigated.About:
This article is published in Oral Oncology.The article was published on 2017-05-01. It has received 190 citations till now. The article focuses on the topics: Oral lichen planus.read more
Citations
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Journal ArticleDOI
Oral potentially malignant disorders: risk of progression to malignancy
TL;DR: This review attempts to identify important risk factors and presents a simple algorithm that can be used as a guide for risk assessment at each stage of the clinical evaluation of a patient.
Journal ArticleDOI
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Saman Warnakulasuriya,Omar Kujan,José Manuel Aguirre-Urizar,Jose V. Bagan,Miguel Ángel González-Moles,Alexander Ross Kerr,Giovanni Lodi,Fernanda Weber Mello,Luís Monteiro,Graham R. Ogden,Philip Sloan,Newell W. Johnson,Newell W. Johnson +12 more
TL;DR: It is recommended the establishment of a global research consortium to further study the natural history of OPMDs based on the classification and nomenclature proposed here, and link them to evidence-based interventions, to facilitate the prevention and management of lip and oral cavity cancer.
Journal ArticleDOI
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype
Oreste Iocca,Thomas P. Sollecito,Faizan Alawi,Gregory S. Weinstein,Jason G. Newman,Armando De Virgilio,Pasquale Di Maio,Giuseppe Spriano,Simón Pardiñas López,Rabie M. Shanti +9 more
TL;DR: Potentially malignant disorders of the oral cavity (OPMD) are a heterogeneous group of lesions associated with a variable risk of malignant transformation (MT) to invasive cancer.
Journal ArticleDOI
Rate of malignant transformation of oral lichen planus: A systematic review.
M. Giuliani,Giuseppe Troiano,Massimo Cordaro,Massimo Corsalini,Gioele Gioco,Lorenzo Lo Muzio,Pamela Pignatelli,Carlo Lajolo +7 more
TL;DR: This systematic review confirms that both OLP and OLL, the latter with a slightly higher TR, may be considered potentially malignant disorders and suggest that erosive type, female gender and tongue site should be considered as risk factors for OLP transformation.
Journal ArticleDOI
Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis.
Miguel Ángel González-Moles,Isabel Ruiz-Ávila,Lucía González-Ruiz,Ángela Ayén,José Antonio Gil-Montoya,Pablo Ramos-García +5 more
TL;DR: The malignant transformation rates of OLP, OLLs and LRs are underestimated due essentially to restrictive diagnostic criteria, inadequate follow-up periods, and/or low quality of studies.
References
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Journal ArticleDOI
Pathogenesis of oral lichen planus – a review
M. R. Roopashree,Rajesh V Gondhalekar,M. C. Shashikanth,Jiji George,S. H. Thippeswamy,Abhilasha Shukla +5 more
TL;DR: Both antigen-specific and non-specific mechanisms are hypothesized to be involved in the pathogenesis of oral lichen planus, a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology.
Journal ArticleDOI
Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy
S. Choi,J.N. Myers +1 more
TL;DR: The rapid progress that has been made in understanding of the molecular alterations contributing to the development of OSCC is leading to improvements in the early diagnosis of tumors and the refinement of biologic treatments individualized to the specific characteristics of a patient’s tumor.
Journal ArticleDOI
Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype.
TL;DR: Results from these studies suggest that the core protein plays an important role in the regulation of HCV-infected cell growth and in the transformation to tumorigenic phenotype, and suggest a possible mechanism for this viral protein in the pathogenesis of hepatocellular carcinoma in HCV -infected humans.
Journal ArticleDOI
A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association.
TL;DR: The onset of lichen planus could not be associated with any evident factors, such as family history, Candida albicans, glucose intolerance, and smoking.
Journal ArticleDOI
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination
TL;DR: It is demonstrated that 8‐nitroguanine is formed dose‐dependently in calf thymus DNA incubated with low concentrations of peroxynitrite in vitro, a strong oxidant formed by reaction of nitric oxide with superoxide in inflamed tissues.