Journal ArticleDOI
Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data.
Sana Maher Hasan Aghbari,Abdelrahman Ibrahim Abushouk,Attia O. Attia,Ahmed Elmaraezy,Amr Menshawy,Mohamed Shehata Ahmed,Basma Elsaadany,Eman Ahmed +7 more
TLDR
A higher incidence of malignant transformation was found among smokers, alcoholics, and HCV-infected patients; however, these associations should be further investigated.About:
This article is published in Oral Oncology.The article was published on 2017-05-01. It has received 190 citations till now. The article focuses on the topics: Oral lichen planus.read more
Citations
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Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus
TL;DR: Renin that is induced by NF-κB pathway contributes to the increase of IL-17 in human oral keratinocytes (HOKs) and is revealed that renin upregulates IL- 17 expression by enhancing STAT4 phosphorylation.
Journal ArticleDOI
Clinical healing of erosive oral lichen planus with tildrakizumab implicates the interleukin-23/interleukin-17 pathway in the pathogenesis of lichen planus.
TL;DR: A 59-year-old lady with a nine-month history of biopsy-proven, severe erosive oral lichen planus (OLP) that was refractory to multiple treatments, who experienced significant clinical improvement after three doses of the anti-interleukin-23 (IL-23) monoclonal antibody tildrakizumab.
Journal ArticleDOI
Diagnostic Criteria of Oral Lichen Planus: A Narrative Review.
TL;DR: The state-of-the-art regarding OLP and OLL is summarized and the challenges faced on making an accurate diagnosis are discussed, aiming to provide a practical guideline for the postgraduates and oral physicians in reaching the diagnosis of these lesions.
Journal ArticleDOI
HCV infection and the risk of head and neck cancer: A meta-analysis.
Daniele Borsetto,Jonathan Fussey,Luca Fabris,Luigia Bandolin,Piergiorgio Gaudioso,Veronica Phillips,Jerry Polesel,Paolo Boscolo-Rizzo +7 more
TL;DR: The results highlighted the importance of surveillance of the upper aerodigestive tract in patients with known chronic HCV infections in order to enable HNSCC early diagnosis and could be a reminder of the possibility of undiagnosed HCV infection to the clinicians treating H NSCC.
References
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
TL;DR: The quality assessment of non-randomized studies is an important component of a thorough meta-analysis of non randomized studies and can dramatically influence the interpretation of meta-analyses, and can even reverse conclusions regarding the effectiveness of an intervention.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.