Management of Hypertriglyceridemia Induced Acute Pancreatitis
Rajat Garg,Tarun Rustagi +1 more
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This article provides a comprehensive review of management of hypertriglyceridemia induced acute pancreatitis with a focus on plasmapheresis, insulin, heparin infusion, and hemofiltration.Abstract:
Hypertriglyceridemia is an uncommon but a well-established etiology of acute pancreatitis leading to significant morbidity and mortality The risk and severity of acute pancreatitis increase with increasing levels of serum triglycerides It is crucial to identify hypertriglyceridemia as the cause of pancreatitis and initiate appropriate treatment plan Initial supportive treatment is similar to management of other causes of acute pancreatitis with additional specific therapies tailored to lower serum triglycerides levels This includes plasmapheresis, insulin, heparin infusion, and hemofiltration After the acute episode, diet and lifestyle modifications along with hypolipidemic drugs should be initiated to prevent further episodes Currently, there is paucity of studies directly comparing different modalities This article provides a comprehensive review of management of hypertriglyceridemia induced acute pancreatitis We conclude by summarizing our treatment approach to manage hypertriglyceridemia induced acute pancreatitisread more
Citations
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Journal ArticleDOI
Hypertriglyceridemia and acute pancreatitis.
TL;DR: The prompt recognition of hypertriglyceridemia in the setting of acute pancreatitis is essential in both the initial and long-term management of this disease and are essential to prevent recurrent acute pancitis.
Journal ArticleDOI
Volanesorsen in the Treatment of Familial Chylomicronemia Syndrome or Hypertriglyceridaemia: Design, Development and Place in Therapy
TL;DR: Volanesorsen is an antisense oligonucleotide (ASO) inhibitor of apoC3, which reduces TG levels by 70–80% which has been shown also to reduce rates of pancreatitis and improve well-being in FCS and reduce TGs and improve insulin resistance in FPLD.
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Omega-3 polyunsaturated fatty acids: anti-inflammatory and anti-hypertriglyceridemia mechanisms in cardiovascular disease.
TL;DR: The evidence shows that Ω-3 fatty acids have a beneficial effect on CVD through reprogramming of TRL metabolism, reducing inflammatory mediators (cytokines and leukotrienes), and modulation of cell adhesion molecules.
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Intravenous Insulin Versus Conservative Management in Hypertriglyceridemia-Associated Acute Pancreatitis.
Sandeep Dhindsa,Anjul Sharma,Ali Al-Khazaali,Sujata Sitaula,Soumya Nadella,Alexis McKee,Stewart G. Albert,Raymond E. Bourey,Paresh Dandona +8 more
TL;DR: The results show that intravenous insulin did not result in a more rapid fall in TG compared with conservative treatment in patients with HAAP, and fasting and intravenous fluids were effective in lowering TG concentrations rapidly, with no further contribution from insulin.
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Treatment of dyslipidemia in kidney transplantation
TL;DR: Rather than using high-dose statin in difficult patients, an association with ezetimibe is suggested, and new lipid-lowering drugs are emerging but their safety and efficacy in KT patients still need to be assessed.
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