Journal ArticleDOI
Manganese Superoxide Dismutase Gene-Modified Mesenchymal Stem Cells Attenuate Acute Radiation-Induced Lung Injury.
Haixu Chen,Hang Xiang,Wen-Huan Xu,Ming Li,Jie Yuan,Juan Liu,Wanjun Sun,Rong Zhang,Jun Li,Zhao-Qi Ren,Xiao-Mei Zhang,Bin Du,Jun Wan,Ben-Yan Wu,Qiang Zeng,Kunlun He,Chao Yang +16 more
TLDR
Evaluated manganese superoxide dismutase (MnSOD) gene-modified mesenchymal stem cells (MSCs) were effective in modulating RILI in mice and had great potential for accelerating from bench to bedside.Abstract:
Radiation-induced lung injury (RILI) is a major clinical complication for radiotherapy in thoracic tumors. An immediate effect of lung irradiation is the generation of reactive oxygen that can produce oxidative damage to DNA, lipids, and proteins resulting in lung cell injury or death. Currently, the medical management of RILI remains supportive. Therefore, there is an urgent need for the development of countermeasures. The present study aimed to evaluate the protective effect of manganese superoxide dismutase (MnSOD) gene–modified mesenchymal stem cells (MSCs) to facilitate the improved recovery of RILI. Here, nonobese diabetic/severe combined immunodeficiency mice received a 13 Gy dose of whole-thorax irradiation, and were then transfused intravenously with MnSOD-MSCs and monitored for 30 days. Lung histopathologic analysis, plasma levels of inflammatory cytokines (interleukin [IL]-1, IL-6, IL-10, and tumor necrosis factor-α), profibrotic factor transforming growth factor-β1, and the oxidative stress fa...read more
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Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia-reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response
Jia Yao,Jun Zheng,Jianye Cai,Kaining Zeng,Chaorong Zhou,Jiebin Zhang,Shihui Li,Hui Li,Liang Chen,Liying He,Huaxin Chen,Hongyuan Fu,Qi Zhang,Gui-hua Chen,Yang Yang,Yingcai Zhang +15 more
TL;DR: It is demonstrated that human umbilical cord MSC‐ EVs (huc‐MSC‐EVs) could protect against IRI‐induced hepatic apoptosis by reducing the infiltration of neutrophils and alleviating oxidative stress in hepatic tissue in vivo.
Journal ArticleDOI
MSC Based Therapies-New Perspectives for the Injured Lung.
Judith Behnke,Sarah Kremer,Tayyab Shahzad,Cho-Ming Chao,Eva Böttcher-Friebertshäuser,Rory E. Morty,Saverio Bellusci,Harald Ehrhardt +7 more
TL;DR: The presented review summarizes the most recent advances and highlights joint mechanisms of MSC action across disease entities which provide the basis to timely tackle this global disease burden.
Journal ArticleDOI
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases.
Luisa H. A. Silva,Mariana A. Antunes,Mariana A. Antunes,Claudia C. dos Santos,Daniel J. Weiss,Fernanda F. Cruz,Fernanda F. Cruz,Patricia R. M. Rocco,Patricia R. M. Rocco +8 more
TL;DR: Strategies to enhance the beneficial effects of MSCs, including preconditioning (under hypoxia, oxidative stress, heat shock, serum deprivation, and exposure to inflammatory biological samples) and genetic manipulation are described.
Journal ArticleDOI
Improved therapeutics of modified mesenchymal stem cells: an update
Dickson Kofi Wiredu Ocansey,Dickson Kofi Wiredu Ocansey,Bing Pei,Yongmin Yan,Hui Qian,Xu Zhang,Wenrong Xu,Fei Mao +7 more
TL;DR: The importance of prosurvival and promigratory abilities of MSCs in their therapeutic applications can never be overemphasized and these abilities are maintained and even further enhanced via MSC modifications against the inhospitable microenvironment during culture and transplantation.
Journal ArticleDOI
Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics.
Hua Qin,Andong Zhao +1 more
TL;DR: A comprehensive review of the mechanisms and optimization of MSC therapy in ARDS is provided and the potentials and possible barriers of M SC therapy for COVID-19 patients with ARDS are highlighted.
References
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Journal Article
Malondialdehyde (MDA) as a lipid peroxidation marker
TL;DR: Malondialdehyde level is commonly known as a marker of oxidative stress and the antioxidant status in cancerous patients.