Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects.
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TLDR
Two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI are compared.Abstract:
Purpose
To compare two methods for assessing the single kidney glomerular filtration rate (SK-GFR) in humans using dynamic contrast-enhanced (DCE)-MRI.
Materials and Methods
Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland-Patlak plot and a compartmental model. MR estimates of the SK-GFR were compared with standard radioisotope measures in a total of 75 kidneys.
Results
Estimates of renal function using both techniques correlated well with radioisotope-assessed SK-GFR (Spearman's ρ = 0.81, Rutland-Patlak; ρ = 0.71, compartmental model). The Rutland-Patlak approach provided a near one-to-one correspondence, while the compartmental method tended to overestimate SK-GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland-Patlak approach.
Conclusion
DCE-MRI of the kidneys provides data that correlate well with reference measures of SK-GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.read more
Citations
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Classic models for dynamic contrast-enhanced MRI.
Steven Sourbron,David L. Buckley +1 more
TL;DR: Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T1 ‐weighted MR images are acquired dynamically after bolus injection of a contrast agent.
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Models and methods for analyzing DCE-MRI: A review
Fahmi Khalifa,Ahmed Soliman,Ayman El-Baz,Mohamed Abou El-Ghar,Tarek El-Diasty,Georgy Gimel'farb,Rosemary Ouseph,Amy C. Dwyer +7 more
TL;DR: Promising theoretical findings and experimental results suggest that DCE-MRI is a clinically relevant imaging modality, which can be used for early diagnosis of different diseases, such as breast and prostate cancer, renal rejection, and liver tumors.
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MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model.
TL;DR: The separable compartment model is feasible for application in humans and sufficiently robust for a pixel analysis, and increased filtration values compared with the Patlak model suggest that the difference in accuracy observed in animal studies is relevant in humans.
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Diffusion and perfusion of the kidney
TL;DR: The current status of functional renal imaging with focus on DWI and DCE-MRI (dynamic contrast-enhanced MRI), as well as BOLD (blood-oxygenation level dependent) MRI, DTI (diffusion tensor imaging) and arterial spin labeling (ASL).
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Technical aspects of MR perfusion.
TL;DR: The aim is to present a concise but complete overview of the technical issues involved in DCE-MRI data acquisition and analysis, and to summarizes the steps that need to be taken to determine the hemodynamic parameters from the measured data.
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