Mena, a new available marker in tumors of salivary glands?
TLDR
The study suggests that Mena protein seems to play a role in malignant transformation and its intensity is correlated with the type and grade of tumor and also with vascular invasion.Abstract:
Mena (mammalian Ena) is an actin regulatory protein involved in cell motility and adhesion. Based on its potential role in malignant transformation revealed in other organs, we analyzed the Mena expression in normal salivary glands (SG) and salivary tumors. Mena expression was determined in normal SG (n=10) and also benign (n=20) and malignant (n=35) lesions of SG. For the immunohistochemical staining we used the anti-Mena antibody. All normal SG and the benign lesions (10 pleomorphic adenomas, 10 Warthin's tumors) were Mena negative. Salivary duct carcinomas (n=5), carcinomas in pleomorphic adenoma (n=5), acinic cell carcinomas (n=5), squamous cell carcinomas (n=10) and high-grade mucoepidermoid carcinomas (n=2) were positive. The lymphomas (n=5) and low-grade mucoepidermoid carcinomas (n=1) were Mena negative. In one case the lymphoblastic cells stained positive for Mena. Some of the endothelial cells, in the peritumoral vessels, were Mena positive. To the best of our knowledge, this is the first study in the literature about Mena expression in salivary tumors. Our study suggests that Mena protein seems to play a role in malignant transformation and its intensity is correlated with the type and grade of tumor and also with vascular invasion. Its positivity in endothelial cells may suggest its potential role in tumor angiogenesis.read more
Citations
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Journal ArticleDOI
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.
Hui Min Zhou,Hui Min Zhou,Yuan Yuan Fang,Paul M. Weinberger,Ling Ling Ding,John K. Cowell,Farlyn Z. Hudson,Mingqiang Ren,Jeffrey R. Lee,Qi Kui Chen,Hong Su,William S. Dynan,William S. Dynan,Ying Lin +13 more
TL;DR: In this article, the role of transgelin in colorectal cancer metastasis was determined by determining whether experimental manipulation of trans-gelin levels in colon cancer cells led to changes in metastatic potential in vivo.
Additional file 1: Table S1. of Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility
Hui-Min Zhou,Yuan-Yuan Fang,Paul M. Weinberger,Ling-Ling Ding,John K. Cowell,Farlyn Z. Hudson,Mingqiang Ren,Jeffrey R. Lee,Qi-Kui Chen,Hong Su,William S. Dynan,Ying Lin +11 more
TL;DR: Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis.
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The possible role of Mena protein and its splicing-derived variants in embryogenesis, carcinogenesis, and tumor invasion: a systematic review of the literature.
TL;DR: It is found that the intensity of Mena expression increased from premalignant to malignant lesions in some organs such as large bowel, stomach, cervix, and salivary glands, and these findings prove that Mena could be a marker ofPremalignant epithelial lesions.
Journal ArticleDOI
A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation.
Paweł Sowa,Karolina Goroszkiewicz,Joanna Szydelko,Joanna Chechlinska,Katarzyna Pluta,Wojciech Domka,Maciej Misiołek,Wojciech Scierski +7 more
TL;DR: The authors used PubMed, Medline, and Google websites to find and review the most significant papers related to malignant transformation in benign salivary gland tumours.
References
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