The possible role of Mena protein and its splicing-derived variants in embryogenesis, carcinogenesis, and tumor invasion: a systematic review of the literature.
TLDR
It is found that the intensity of Mena expression increased from premalignant to malignant lesions in some organs such as large bowel, stomach, cervix, and salivary glands, and these findings prove that Mena could be a marker ofPremalignant epithelial lesions.Abstract:
The Ena/VASP (enabled/vasodilator stimulated phosphoprotein) family includes the binding actin proteins such as mammalian Ena (Mena), VASP, and Ena-VASP-like. It is known that the perturbation of actin cycle could determine alteration in the mobility of cells and in consequence of organogenesis. Few recent studies have revealed that Mena protein could play a role in breast or pancreatic carcinogenesis. Based on our researches, we observed that the intensity of Mena expression increased from premalignant to malignant lesions in some organs such as large bowel, stomach, cervix, and salivary glands. These findings prove that Mena could be a marker of premalignant epithelial lesions. In premalignant lesions, it could be helpful to define more accurately the risk for malignant transformation. In malignant tumors, correlation of expression of its splice variants could indicate metastatic behavior. In conclusion, we consider that it is necessary to analyze the expression of Mena splice variants in a higher number of cases, in different epithelial lesions, and also in experimental studies to define its exact role in carcinogenesis and also its possible prognostic and predictive values.read more
Citations
More filters
Journal ArticleDOI
I and i
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Journal ArticleDOI
Filopodia in cell adhesion, 3D migration and cancer cell invasion.
TL;DR: This review discusses recent advances demonstrating that filopodia are involved in substrate tethering and environment sensing in vivo and the emerging role offilopodial proteins in tumor dissemination as mounting in vitro and in vivo.
A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Ulrike Philippar,Evanthia T. Roussos,Matthew G. Oser,Hideki Yamaguchi,Hideki Yamaguchi,Hyung-Do Kim,Silvia Giampieri,Yarong Wang,Sumanta Goswami,Sumanta Goswami,Jeffrey B. Wyckoff,Douglas A. Lauffenburger,Erik Sahai,Erik Sahai,John S. Condeelis,Frank B. Gertler +15 more
TL;DR: In this paper, Mena and Mena(INV) were shown to promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis.
Book ChapterDOI
Roles and Regulation of Epithelial Splicing Regulatory Proteins 1 and 2 in Epithelial-Mesenchymal Transition.
TL;DR: The regulation of ESRP activity is discussed, as well as the evidence supporting a causal role of E SRPs in EMT, and the epithelial splicing regulatory proteins 1 and 2 have been described as epithelial-specific splicing master regulators specifically involved in E MT-associated alternative splicing.
Journal ArticleDOI
Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes
Xiaoyuan Xu,He Jiang,Xingnuan Li,Ping Wu,Jianyun Liu,Tao Wang,Xiaoou Zhou,Jianjun Xiong,Weidong Li +8 more
TL;DR: The results of the present study suggested that miRNAs (miR-203 and miR-382) and DEGs (NEGR1, PPAP2B, PDGFRA, IL6ST and SORT1) may serve pivotal functions in the osteoblastic differentiation of MSCs, whereas niR-495, which is also involved in osteoblast differentiation and had four targets, may have crucial roles in adipocytic differentiation.
References
More filters
Journal ArticleDOI
I and i
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Journal ArticleDOI
Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration.
TL;DR: Phosphorylation by PKA/PKG serine/threonine kinases appears to modulate Ena/VASP function within cells, although the mechanism underlying this regulation remains to be determined.
Journal ArticleDOI
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.
TL;DR: Two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein) are identified, supporting a role for this protein in microfilament assembly and cell motility.
Journal ArticleDOI
Negative Regulation of Fibroblast Motility by Ena/VASP Proteins
TL;DR: Using overexpression, loss-of-function, and inhibitory approaches, it is found that Ena/VASP proteins negatively regulate fibroblast motility.
Journal ArticleDOI
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.
Thomas Deller,Martin Korte,Sophie Chabanis,Alexander Drakew,Herbert Schwegler,Giulia Good Stefani,Aimée Zuniga,Karin Schwarz,Tobias Bonhoeffer,Rolf Zeller,Michael Frotscher,Peter Mundel +11 more
TL;DR: It is reported that mice homozygous for a targeted deletion of the synaptopodin gene completely lack spine apparatuses, and this absence is accompanied by a reduction in hippocampal long-term potentiation in the CA1 region of the hippocampus and by an impairment of spatial learning in the radial arm maze test.