Meningeal dissemination in primary CNS lymphoma: diagnosis, treatment, and survival in a large monocenter cohort
TLDR
No impact on outcome was seen for MD, diagnosed by any of the methods used; however, patients with cytomorphologic proof of MD had a significantly shorter median EFS and OAS.Abstract:
The frequency of meningeal dissemination (MD) in primary CNS lymphoma (PCNSL), its prognostic impact, and optimal management have not been defined thus far. In 69 of 92 (75%) immunocompetent patients, primarily diagnosed with PCNSL at our institution between January 1994 and February 2007, cerebrospinal fluid was analyzed for MD. MD was found by cytomorphology in 7/63 (11%), by immunophenotyping in 1/32 (3%), and by PCR of the IgH CDR III region in 6/37 (16%). Neuroradiologic examination revealed MD in 3 of 69 patients (4%). Median event-free survival (EFS) of patients with MD diagnosed by any of the methods was 26 months, of those without MD 34.1 months (P = .24); median overall survival (OAS) of these two patients' groups was 45.5 and 42.5 months, respectively (P = .34). Patients with cytomorphologic proof of MD had a median EFS of 15.4 months and OAS of 18.5 months, those without MD 34.3 and 45 months (P = .018 and .017, respectively). We found a low frequency of MD despite the use of putatively sensitive diagnostic methods. No impact on outcome was seen for MD, diagnosed by any of the methods used; however, patients with cytomorphologic proof of MD had a significantly shorter median EFS and OAS.read more
Citations
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Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system
Alexander Baraniskin,Jan Kuhnhenn,Uwe Schlegel,Andrew T. Chan,Martina Deckert,Ralf Gold,Abdelouahid Maghnouj,Hannah Zöllner,Anke Reinacher-Schick,Wolff Schmiegel,Stephan A. Hahn,Roland Schroers +11 more
TL;DR: CSF miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of PCNSL and combined miRNA analyses resulted in an increased diagnostic accuracy and a remarkable stability of mi RNAs in the CSF.
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Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma
Christian Grommes,James L. Rubenstein,Lisa M. DeAngelis,Andrés J.M. Ferreri,Tracy T. Batchelor +4 more
TL;DR: The epidemiology, clinical presentation, staging evaluation, prognosis, and current up-to-date treatment of immunocompetent PCNSL patients are overviewed.
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Current strategies in the diagnosis of diffuse large B-cell lymphoma of the central nervous system.
Alexander Baraniskin,Martina Deckert,Gernot Schulte-Altedorneburg,Uwe Schlegel,Roland Schroers +4 more
TL;DR: Progress in cytopathological, immunophenotypic, and molecular genetic analyses of the cerebrospinal fluid (CSF) has been achieved recently and potentially will facilitate lymphoma diagnosis in the future.
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Diagnosis of leptomeningeal disease in diffuse large B-cell lymphomas of the central nervous system by flow cytometry and cytopathology
Roland Schroers,Alexander Baraniskin,Christoph Heute,Matthias Vorgerd,Anna Brunn,Jan Kuhnhenn,Annika Kowoll,Andriy Alekseyev,Wolff Schmiegel,Uwe Schlegel,Martina Deckert,Hendrik Pels +11 more
TL;DR: It is suggested that multi‐parameter flow cytometry increases the sensitivity and specificity of leptomeningeal disease detection in CNS lymphomas and conventional cytopathology should be applied concurrently for complementary diagnostic assessment in patients with CNS lymphoma.
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