Journal ArticleDOI
Mesothelin-family proteins and diagnosis of mesothelioma.
Bruce W. S. Robinson,Jenette Creaney,Richard A. Lake,Anna K. Nowak,A. William Musk,Nicholas de Klerk,Pernilla Winzell,Karl Erik Hellström,Ingegerd Hellstrom +8 more
TLDR
Determined serum concentrations of soluble mesothelin-related proteins (SMR) in serum could be a useful marker for diagnosis of mesothelioma and to monitor disease progression and might also prove helpful for screening asbestos-exposed individuals for early evidence of mesosarcoma.About:
This article is published in The Lancet.The article was published on 2003-11-15. It has received 514 citations till now. The article focuses on the topics: Mesothelioma & Mesothelin.read more
Citations
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Journal ArticleDOI
Advances in Malignant Mesothelioma
TL;DR: The authors review advances made in the past 5 to 10 years in the understanding, diagnosis, and management of mesothelioma.
Journal ArticleDOI
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
Carmine Carpenito,Michael C. Milone,Raffit Hassan,Jacqueline C. Simonet,Mehdi Lakhal,Megan M. Suhoski,Angel Varela-Rohena,Kathleen M. Haines,Daniel F. Heitjan,Steven M. Albelda,Richard G. Carroll,James L. Riley,Ira Pastan,Carl H. June +13 more
TL;DR: Genetically redirected T cells have promise of targeting T lymphocytes to tumor antigens, confer resistance to the tumor microenvironment, and providing immunosurveillance in the context of poorly immunogenic tumors.
Journal ArticleDOI
Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline 2010
TL;DR: This guideline includes a review of recent evidence for the use of new biomarkers including N-terminal pro-brain natriuretic peptide (NT-proBNP), mesothelin and surrogate markers of tuberculous pleuritis.
Journal ArticleDOI
Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma
Arnaud Scherpereel,Philippe Astoul,Paul Baas,Thierry Berghmans,H Clayson,P. De Vuyst,Hendrik Dienemann,Françoise Galateau-Sallé,Christophe Hennequin,Gunnar Hillerdal,C. Le Pechoux,Luciano Mutti,Jean-Claude Pairon,R. Stahel,P. Van Houtte,J. Van Meerbeeck,David A. Waller,Walter Weder +17 more
TL;DR: It is emphasised that patients who are considered candidates for a multimodal approach should be included in a prospective trial at a specialised centre, and a three step pre-treatment assessment is proposed.
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Mesothelin: A new target for immunotherapy
TL;DR: A soluble mesothelin variant has been identified and could be a useful tumor marker for malignant mesotheliomas and SS1(dsFv)PE38 is a recombinant anti-mesothelin immunotoxin that is undergoing clinical evaluation in patients with Mesothelin-expressing tumors.
References
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Journal Article
Mesothelin Is Overexpressed in the Vast Majority of Ductal Adenocarcinomas of the Pancreas: Identification of a New Pancreatic Cancer Marker by Serial Analysis of Gene Expression (SAGE)
Pedram Argani,Christine A. Iacobuzio-Donahue,Byungwoo Ryu,Christophe Rosty,Michael Goggins,Robb E. Wilentz,Selva R. Murugesan,Steven D. Leach,Elizabeth M. Jaffee,Charles J. Yeo,John L. Cameron,Scott E. Kern,Ralph H. Hruban +12 more
TL;DR: Mesothelin is a new marker for pancreatic adenocarcinoma identified by gene expression analysis and has potential diagnostic, imaging, and therapeutic implications.
Journal ArticleDOI
Tumor-specific CD4+ T cells have a major "post-licensing" role in CTL mediated anti-tumor immunity
Amanda L. Marzo,Beverley F. Kinnear,Richard A. Lake,Jeffrey J. Frelinger,Edward J. Collins,Bruce W. S. Robinson,Bernadette Scott +6 more
TL;DR: The data suggest that there is a correlation among the number of CD8+ T cells, in vivo CTL function, and IFN-γ production, with no evidence of a partial or nonresponsive phenotype among tetramer-positive cells.
Journal ArticleDOI
The Role of Serum Alpha-Fetoprotein estimation in the Diagnosis and Management of Hepatocellular Carcinoma
TL;DR: There is preliminary evidence that changes in serum AFP may be a more accurate and sensitive way of determining the degree of response to treatment than conventional imaging procedures that rely on physical determination of tumor size.
Journal ArticleDOI
Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma
Nathalie Scholler,Ning Fu,Yi Yang,Zhengmao Ye,Gary E. Goodman,Karl Erik Hellström,Ingegerd Hellstrom +6 more
TL;DR: A new member of the mesothelin/MPF family was discovered, which has an 82-bp insert in the membrane-associated part, leading to a frameshift of 212 bp, and whose predicted molecular structure indicates that it is soluble.
Journal ArticleDOI
Cisplatin and Gemcitabine Treatment for Malignant Mesothelioma: A Phase II Study
Michael J. Byrne,J.A. Davidson,Arthur W. Musk,J. Dewar,G. Van Hazel,M. Buck,N. H. de Klerk,Bruce W. S. Robinson +7 more
TL;DR: Combined cisplatin and gemcitabine is an active combination in malignant mesothelioma and produces symptomatic benefit in responding patients and shows significant increase during the time of remission.
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