Journal ArticleDOI
Advances in Malignant Mesothelioma
TLDR
The authors review advances made in the past 5 to 10 years in the understanding, diagnosis, and management of mesothelioma.Abstract:
Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and the peritoneum. This tumor was once rare, but its incidence is increasing worldwide, probably as a result of widespread exposure to asbestos, a factor with which it is associated. The authors review advances made in the past 5 to 10 years in the understanding, diagnosis, and management of mesothelioma.read more
Citations
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Lung cancer: Biology and treatment options
TL;DR: The purpose of this review is to summarize the recent developments in lung cancer biology and its therapeutic strategies, and discuss the latest treatment advances including therapies currently under clinical investigation.
Journal ArticleDOI
Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma
Arnaud Scherpereel,Philippe Astoul,Paul Baas,Thierry Berghmans,H Clayson,P. De Vuyst,Hendrik Dienemann,Françoise Galateau-Sallé,Christophe Hennequin,Gunnar Hillerdal,C. Le Pechoux,Luciano Mutti,Jean-Claude Pairon,R. Stahel,P. Van Houtte,J. Van Meerbeeck,David A. Waller,Walter Weder +17 more
TL;DR: It is emphasised that patients who are considered candidates for a multimodal approach should be included in a prospective trial at a specialised centre, and a three step pre-treatment assessment is proposed.
Journal ArticleDOI
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: Multi-Institutional Experience
Tristan D. Yan,Marcello Deraco,Dario Baratti,Shigeki Kusamura,Dominique Elias,Olivier Glehen,François Noël Gilly,Edward A. Levine,Perry Shen,Faheez Mohamed,Brendan Moran,David L. Morris,Terence C. Chua,Pompiliu Piso,Paul H. Sugarbaker +14 more
TL;DR: CRS combined with HIPEC achieved prolonged survival in selected patients with DMPM, and four prognostic factors were independently associated with improved survival in the multivariate analysis.
Journal ArticleDOI
Chronic inflammation: a common and important factor in the pathogenesis of neoplasia.
TL;DR: Future research on the complex cascade of cellular and humoral factors participating in the chronic inflammatory process will further understanding of the pathogenesis of various cancers and potentially provide a rationale for targeted chemopreventive interventions.
Journal ArticleDOI
Malignant pleural mesothelioma
TL;DR: The major clinical trials that impact mesothelioma treatment in the resectable and unresectable settings are provided, the role of extrapleural pneumonectomy, adjuvant radiotherapy, and use of intensity-modulated radiotherapy versus hemithoracic therapy are addressed.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma
Nicholas J. Vogelzang,James J. Rusthoven,James T. Symanowski,Claude Denham,E. Kaukel,Pierre Ruffié,Ulrich Gatzemeier,Michael Boyer,Salih Emri,Christian Manegold,Clet Niyikiza,Paolo Paoletti +11 more
TL;DR: Treatment with pemetrexed plus cisplatin and vitamin supplementation resulted in superior survival time, time to progression, and response rates compared with treatment with cis Platin alone in patients with malignant pleural mesothelioma.
Journal ArticleDOI
Molecular mechanisms of caspase regulation during apoptosis
Stefan J. Riedl,Yigong Shi +1 more
TL;DR: The present understanding of caspase regulation during apoptosis is described and biochemical and structural studies have led to important advances in understanding the underlying molecular mechanisms of cispase regulation.
Journal ArticleDOI
Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province.
TL;DR: In a majority of cases of diffuse pleural mesothelioma, all but one have a probable exposure to crocidolite asbestos (Cape blue) in the Asbestos Hills which lie to the west of Kimberley in the north west of Cape Province.
Journal Article
Translation of microarray data into clinically relevant cancer diagnostic tests using gene expression ratios in lung cancer and mesothelioma.
Gavin J. Gordon,Roderick V. Jensen,Li Li Hsiao,Steven R. Gullans,Joshua E. Blumenstock,Sridhar Ramaswamy,William G. Richards,David J. Sugarbaker,Raphael Bueno +8 more
TL;DR: It is proposed that using gene expression ratios is an accurate and inexpensive technique with direct clinical applicability for distinguishing between MPM and lung cancer and evidence is provided suggesting that this technique can be equally accurate in other clinical scenarios.