Journal ArticleDOI
Meta-analysis: Accuracy of 18FDG PET-CT for distant metastasis staging in lung cancer patients
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TLDR
FDG PET-CT has excellent diagnostic performance for diagnosis of distant metastases in patients with lung cancer, and its sensitivity, specificity, positive likelihood ratio and negative likelihood ratio are excellent.Abstract:
Background We undertook a meta-analysis to evaluate the accuracy of 18 FDG PET-CT for diagnosis of distant metastases in lung cancer patients. Methods Studies about 18 FDG PET-CT for diagnosis of distant metastases in patients with lung cancer were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, positive likelihood ratios and negative likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for 18 FDG PET-CT. Results Across 9 studies (780 patients), the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of 18 FDG PET-CT were 0.93 (95% confidence interval [CI] = 0.88–0.96), 0.96 (95% CI = 0.95–0.96), 28.4 (95% CI = 14.0–57.5), and 0.08 (95% CI = 0.02–0.37), respectively. Overall weighted area under the curve was 0.98 (95% CI = 0.96–0.99). Conclusion 18 FDG PET-CT has excellent diagnostic performance for diagnosis of distant metastases in patients with lung cancer.read more
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Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis.
Hyung Jun Im,Kyoungjune Pak,Kyoungjune Pak,Gi Jeong Cheon,Keon Wook Kang,Seong Jang Kim,In Joo Kim,June-Key Chung,E. Edmund Kim,Dong Soo Lee +9 more
TL;DR: Volumetric parameters from 18F-FDG PET are significant prognostic factors for outcome in patients with NSCLC and patients with a high MTV or TLG are at higher risk of adverse events and death.
Journal ArticleDOI
Role of FDG PET/CT in the Eighth Edition of TNM Staging of Non-Small Cell Lung Cancer.
TL;DR: The eighth edition of the TNM staging system for lung cancer is reviewed, as well as the role of FDG PET/CT in the staging of non-small cell lung carcinoma.
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FDG PET-CT for solitary pulmonary nodule and lung cancer: Literature review.
David Groheux,G. Quere,Estelle Blanc,C. Lemarignier,Laetitia Vercellino,C. de Margerie-Mellon,Pascal Merlet,S. Querellou +7 more
TL;DR: This literature review attempts to clarify how PET imaging contributes to investigating SPN, in conjunction with conventional CT, and analyzes the current role of PET-CT in the overall care process for lung cancer.
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18F-FDG PET/CT in non-small-cell lung cancer patients: a potential predictive biomarker of response to immunotherapy.
Laura Evangelista,Lea Cuppari,Jessica Menis,Laura Bonanno,Pasquale Reccia,Stefano Frega,Giulia Pasello +6 more
TL;DR: The entire tumor burden evaluated by F-FDG PET/CT can be predictive of response to immunotherapy in patients with metastatic lung cancer.
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Radiotherapy for Oligometastatic Lung Cancer.
TL;DR: Current retrospective and prospective clinical evidence support the existence of an oligometastatic disease state wherein select individuals with advanced NSCLC may experience historically unprecedented prolonged survival with aggressive local treatments, consisting of radiotherapy and/or surgery, to limited sites of metastatic disease.
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Users' Guides to the Medical Literature: III. How to Use an Article About a Diagnostic Test: B. What Are the Results and Will They Help Me In Caring for My Patients?
TL;DR: The patient is a 28-year-old man whose acute onset of shortness of breath and vague chest pain began shortly after completing a 10-hour auto trip, and the physician is very apprehensive about his symptoms.
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Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group.
TL;DR: You are back where you were in the previous article1 on diagnostic tests: in the library studying an article that will guide you in interpreting ventilation-perfusion (V/Q) lung scans.