Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives
Yusuf Oloruntoyin Ayipo,Yusuf Oloruntoyin Ayipo,W. A. Osunniran,H. F. Babamale,H. F. Babamale,Monsurat Olabisi Ayinde,Mohd Nizam Mordi +6 more
TLDR
A comprehensive review of the coordination chemistry of metalloenzymes in the resistance development and modulatory potentials of metal-chelating and metal complex inhibitors for catalytic deactivation is presented in this paper.About:
This article is published in Coordination Chemistry Reviews.The article was published on 2021-11-24 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Chemistry.read more
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Computational modelling of potential Zn-sensitive non-β-lactam inhibitors of imipenemase-1 (IMP-1).
Yusuf Oloruntoyin Ayipo,Iqrar Ahmad,Waleed Abdullah Ahmad Alananzeh,A Lawal,Harun M. Patel,Mohd Nizam Mordi +5 more
TL;DR: In this article , computational molecular modelling and virtual screening methods were extensively applied to identify new putative Zn-sensitive broad-spectrum inhibitors of MBLs, specifically imipenemase-1 (IMP-1) from the IBScreen database.
Journal ArticleDOI
Epigenetic oncogenesis, biomarkers and emerging chemotherapeutics for breast cancer.
TL;DR: In this paper , a review of epigenetics studies of several pathways to breast cancer oncogenesis via the inducement of oncogenic changes on relevant markers have been overviewed, and the counter-epigenetic mechanisms to reverse such changes as effective therapeutic strategies were surveyed.
Journal ArticleDOI
Targeting Warburg effect to rescue the suffocated photodynamic therapy: A cancer-specific solution.
Yaoquan Su,Ke Shuai Lu,Yuhang Huang,Jingyu Zhang,Xiaolian Sun,Juanjuan Peng,Yunyun Zhou,Lingzhi Zhao +7 more
TL;DR: In this article , the authors employed the glucose metabolism as the cancer-specific target to enhance the performance of photodynamic therapy (PDT) to address the tumor hypoxia problem.
Journal ArticleDOI
Bioinspired Active Site with a Coordination-Adaptive Organosulfonate Ligand for Catalytic Water Oxidation at Neutral pH
Tianqi Liu,Shaoqi Zhan,Nannan Shen,Linqin Wang,Zoltán Szabó,Hao Yang,Mårten S. G. Ahlquist,Licheng Sun +7 more
TL;DR: In this paper , a Ru-based molecular water oxidation catalyst containing a configurationally labile ligand was designed to mimic enzymatic framework, in which the sulfonate coordination is highly flexible and functions as both an electron donor to stabilize high-valent Ru and a proton acceptor to accelerate water dissociation, thus boosting the catalytic water oxidation performance thermodynamically and kinetically.
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Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives
Rajwinder Kaur,Kirandeep Kaur,Mohammad H. Alyami,Damanpreet Kaur Lang,Balraj Saini,Mohammad F. Bayan,Balakumar Chandrasekaran +6 more
TL;DR: In this article , a structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, for the present review.
References
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Genetic Analysis of Human Norovirus Strains in Japan in 2016-2017.
Koo Nagasawa,Yuki Matsushima,Takumi Motoya,Fuminori Mizukoshi,Yo Ueki,Naomi Sakon,Koichi Murakami,Tomomi Shimizu,Nobuhiko Okabe,Noriko Nagata,Komei Shirabe,Hiroto Shinomiya,Wataru Suzuki,Makoto Kuroda,Tsuyoshi Sekizuka,Yoshiyuki Suzuki,Akihide Ryo,Kiyotaka Fujita,Kazunori Oishi,Kazuhiko Katayama,Hirokazu Kimura,Hirokazu Kimura +21 more
TL;DR: The time-scale phylogeny suggested that the common ancestors of the 2016 strains VP1 gene and RdRp region diverged in 2006 and 1999, respectively, and that the 2016 strain was the progeny of a pre-2016 GII.2.2 strains.
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RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences.
Stephen K. Burley,Charmi Bhikadiya,Chunxiao Bi,Sebastian Bittrich,Li Chen,Gregg V. Crichlow,Cole Christie,Kenneth Dalenberg,Luigi Di Costanzo,Jose M. Duarte,Shuchismita Dutta,Zukang Feng,Sai J. Ganesan,David S. Goodsell,David S. Goodsell,Sutapa Ghosh,Rachel Kramer Green,Vladimir Guranovic,Dmytro Guzenko,Brian P. Hudson,Catherine L. Lawson,Yu-He Liang,Robert Lowe,Harry Namkoong,Ezra Peisach,Irina Persikova,Christopher Randle,Alexander S. Rose,Yana Rose,Andrej Sali,Joan Segura,Monica Sekharan,Chenghua Shao,Yi-Ping Tao,Maria Voigt,John D. Westbrook,Jasmine Young,Christine Zardecki,Marina Zhuravleva +38 more
TL;DR: New features and resources of the RCSB PDB have been described in detail using examples that showcase recently released structures of SARS-CoV-2 proteins and host cell proteins relevant to understanding and addressing the COVID-19 global pandemic.
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Correction: Corrigendum: The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
Zenggang Li,Andrei A. Ivanov,Rina Su,Valentina Gonzalez-Pecchi,Qi Qi,Songlin Liu,Philip J. Webber,Elizabeth A. McMillan,Lauren Rusnak,Cau Pham,Xiaoqian Chen,Xiulei Mo,Brian Revennaugh,Wei Zhou,Adam I. Marcus,Sahar Harati,Xiang Chen,Margaret A. Johns,Michael A. White,Carlos S. Moreno,Lee Cooper,Yuhong Du,Fadlo R. Khuri,Haian Fu +23 more
TL;DR: This work presents a new probabilistic procedure that allows for direct measurement of the response of the immune system to EMTs and shows real-time recognition of EMT activity in the response to EMMARM.
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Metalloproteins containing cytochrome, iron-sulfur, or copper redox centers.
Jing Liu,Saumen Chakraborty,Parisa Hosseinzadeh,Yang Yu,Shiliang Tian,Igor D. Petrik,Ambika Bhagi,Yi Lu +7 more
TL;DR: Through this review, structural features responsible for their redox properties are examined, including knowledge gained from recent progress in fine-tuning the redox centers.
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Past and Present Perspectives on β-Lactamases.
TL;DR: New enzyme variants continue to be described, partly because of the ease of obtaining sequence data from whole-genome sequencing studies, but often these new enzymes are devoid of any phenotypic descriptions, making it more difficult for clinicians and antibiotic researchers to address new challenges that may be posed by unusual β-lactamases.