Journal ArticleDOI
Mexican antidiabetic herbs: valuable sources of inhibitors of α-glucosidases.
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TLDR
Four species have been thoroughly analyzed in order to discover novel α-glucosidase inhibitors, namely, HintonIA latiflora and Hintonia standleyana (Rubiaceae), Ligusticum porteri (Apiaceae), and Brickellia cavanillesii (Asteraceae).Abstract:
Type II-diabetes mellitus (TII-DM) has been regarded as one of the most important public health problems in all nations in the 21st century. Although allopathic therapies remain the most important for the initial management of TII-DM, herbal remedies have gained wide acceptance for treating this condition. These alternative therapies are particularly valued in countries such as Mexico, rich in medicinal plants strongly attached to the cultural values of the population. Medicinal plants are prized sources of α-glucosidase inhibitors, which delay the liberation of glucose from complex carbohydrates, retarding glucose absorption, and thus controlling the characteristic hyperglycemia of TII-DM. Among the plant species used for treating diabetes in Mexico only 38 have been analyzed for their inhibitory activity of α-glucosidases. Most of these studies, reviewed in the present work, have focused on the evaluation of different types of extracts on the activity of α-glucosidases from diverse sources. Four species have been thoroughly analyzed in order to discover novel α-glucosidase inhibitors, namely, Hintonia latiflora and Hintonia standleyana (Rubiaceae), Ligusticum porteri (Apiaceae), and Brickellia cavanillesii (Asteraceae). Their ethnomedical uses, pharmacological and toxicological studies, chemical composition, and antihyperglycemic principles with α-glucosidase inhibitory activity are summarized.read more
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Journal ArticleDOI
Natural Products for the Treatment of Type 2 Diabetes Mellitus
TL;DR: This review compiles the principal articles on medicinal plants used for treating diabetes and its comorbidities, as well as mechanisms of natural products as antidiabetic agents, and considers compounds of high interest as potential antidiabetics.
Journal ArticleDOI
α-Glucosidase inhibitors isolated from medicinal plants
TL;DR: Compounds with α -glucosidase inhibitory activity are abundant in nature and can be obtained from several sources, and they can be clinically developed for treating diabetes mellitus.
Journal ArticleDOI
Isocoumarins and benzofurans from the mangrove endophytic fungus Talaromyces amestolkiae possess α-glucosidase inhibitory and antibacterial activities
TL;DR: Six new isocoumarins, compounds 1–4 and 14–15, two new benzofurans, 16–17, along with nine known isocOUmarin analogues, 5–13 were obtained from the mangrove endophytic fungus Talaromyces amestolkiae YX1 and their structures were elucidated by analysis of spectroscopic data.
Journal ArticleDOI
Magnetic Ligand Fishing as a Targeting Tool for HPLC-HRMS-SPE-NMR: α-Glucosidase Inhibitory Ligands and Alkylresorcinol Glycosides from Eugenia catharinae.
TL;DR: A bioanalytical platform combining magnetic ligand fishing for α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR for structural identification of α- glucosinase inhibitory ligands, both directly from crude plant extracts, is presented.
Journal ArticleDOI
Hancornia speciosa Gomes (Apocynaceae) as a potential anti-diabetic drug
Aline Carvalho Pereira,Ana Bárbara Dias Pereira,Carolina Campos Lima Moreira,Leida Maria Botion,Virginia S. Lemos,Fernão Castro Braga,Steyner F. Cortes +6 more
TL;DR: Hancornia speciosa has a potential anti-diabetic effect through a mechanism dependent on inhibition of α-glucosidase and increase on glucose uptake and these results give support to the use on traditional medicine of this medicinal plant.
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