Journal ArticleDOI
MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
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This article is published in Cell.The article was published on 1994-01-28. It has received 1448 citations till now. The article focuses on the topics: Antigen processing & T lymphocyte.read more
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B lymphocytes secrete antigen-presenting vesicles.
Graça Raposo,Hans W. Nijman,Willem Stoorvogel,R Liejendekker,Clifford V. Harding,Cornelis J. M. Melief,Hans J. Geuze +6 more
TL;DR: It is demonstrated by immunoelectron microscopy that the limiting membrane of MIICs can fuse directly with the plasma membrane, resulting in release from the cells of internal MHC class II-containing vesicles, suggesting a role for exosomes in antigen presentation in vivo.
Journal ArticleDOI
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
Laurence Zitvogel,Armelle Regnault,A. Lozier,Joseph Wolfers,Caroline Flament,Danielle Tenza,Paola Ricciardi-Castagnoli,Graça Raposo,Sebastian Amigorena +8 more
TL;DR: Dendritic cells are shown to secrete antigen presenting vesicles, called exosomes, which express functional Major Histocompatibility Complex class I and class II, and T-cell costimulatory molecules, which prime specific cytotoxic T lymphocytes in vivo.
Journal ArticleDOI
The instructive role of innate immunity in the acquired immune response.
TL;DR: Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops but may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response.
Journal ArticleDOI
Immunological Memory and Protective Immunity: Understanding Their Relation
Rafi Ahmed,David Gray +1 more
TL;DR: The current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.
Journal ArticleDOI
Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview.
TL;DR: The findings suggest that Au(0) nanoparticles are not cytotoxic, reduce the production of reactive oxygen and nitrite species, and do not elicit secretion of proinflammatory cytokines TNF-alpha and IL1-beta, making them suitable candidates for nanomedicine.
References
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Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal ArticleDOI
The dendritic cell system and its role in immunogenicity
TL;DR: Dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells.
Journal ArticleDOI
Structure of the human class I histocompatibility antigen, HLA-A2.
Pamela J. Bjorkman,Mark A. Saper,Boudjéma Samraoui,W. S. Bennett,W. S. Bennett,Jack L. Strominger,Don C. Wiley +6 more
TL;DR: The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner and the region distal from the membrane is a platform of eight antiparallel β-strands topped by α-helices.
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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules.
TL;DR: Each MHC class I allele has its individual rules to which peptides presented in the groove adhere, and this information about the contents of MHC grooves is now provided.
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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
Jerry H. Brown,Theodore S. Jardetzky,Joan C. Gorga,Joan C. Gorga,Lawrence J. Stern,Lawrence J. Stern,Robert G. Urban,Jack L. Strominger,Don C. Wiley,Don C. Wiley +9 more
TL;DR: A dimer of the class II αβ heterodimers is seen in the crystal forms of HLA-DR1, suggesting class II HLA dimerization as a mechanism for initiating the cytoplasmic signalling events in T-cell activation.