Journal ArticleDOI
Microfluidic chip-based liquid chromatography coupled to mass spectrometry for determination of small molecules in bioanalytical applications
TLDR
This mini‐review summarizes the utilization of commercial chip‐based LC‐MS systems for determination of small molecules in bioanalytical applications, including drug metabolites and disease/tumor‐associated biomarkers in clinical samples as well as adsorption, distribution, metabolism, and excretion studies of APIs in drug discovery and development.Abstract:
The development and integration of microfabricated liquid chromatography (LC) microchips have increased dramatically in the last decade due to the needs of enhanced sensitivity and rapid analysis as well as the rising concern on reducing environmental impacts of chemicals used in various types of chemical and biochemical analyses. Recent development of microfluidic chip-based LC mass spectrometry (chip-based LC-MS) has played an important role in proteomic research for high throughput analysis. To date, the use of chip-based LC-MS for determination of small molecules, such as biomarkers, active pharmaceutical ingredients (APIs), and drugs of abuse and their metabolites, in clinical and pharmaceutical applications has not been thoroughly investigated. This mini-review summarizes the utilization of commercial chip-based LC-MS systems for determination of small molecules in bioanalytical applications, including drug metabolites and disease/tumor-associated biomarkers in clinical samples as well as adsorption, distribution, metabolism, and excretion studies of APIs in drug discovery and development. The different types of commercial chip-based interfaces for LC-MS analysis are discussed first and followed by applications of chip-based LC-MS on biological samples as well as the comparison with other LC-MS techniques.read more
Citations
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Journal ArticleDOI
Recent developments in liquid chromatography-mass spectrometry and related techniques.
TL;DR: This review summarizes the state-of-art in liquid chromatography-mass spectrometry (LC-MS) and related techniques with the main focus on recent developments in the last decade.
Journal ArticleDOI
Application of microfluidic chip technology in pharmaceutical analysis: A review.
Ping Cui,Sicen Wang +1 more
TL;DR: This review highlights the latest (2010–2018) microfluidic technology for drug analysis and discusses the potential future development in this field.
Journal ArticleDOI
Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening
TL;DR: This review presents a curated selection of state-of-the-art microfluidic platforms focusing on the fabrication, characterization, and assessment of nanoparticles for drug delivery applications, and discusses the current challenges and future prospects of nanoparticle drug delivery development using microfluids.
Journal ArticleDOI
Analytical techniques for metabolomic studies: a review.
TL;DR: The most commonly used analytical techniques for metabolomic studies are discussed, including their advantages, drawbacks and some applications.
Journal ArticleDOI
Recent advances in microfluidics combined with mass spectrometry: technologies and applications
TL;DR: The latest achievements since 2008 in the field of the technologies and applications in the combining of microfluidics with ESI-MS and MALDI-MS are summarized.
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