R
Rudolf Grimm
Researcher at Agilent Technologies
Publications - 93
Citations - 6002
Rudolf Grimm is an academic researcher from Agilent Technologies. The author has contributed to research in topics: Mass spectrometry & Nuclear matrix. The author has an hindex of 40, co-authored 92 publications receiving 5627 citations. Previous affiliations of Rudolf Grimm include Chungnam National University & Hewlett-Packard.
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Journal ArticleDOI
A strategy for annotating the human milk glycome
Milady R. Niñonuevo,Youmie Park,Hongfeng Yin,Jinhua Zhang,Robert Ward,Brian H. Clowers,J. Bruce German,Samara L. Freeman,Kevin Killeen,Rudolf Grimm,Carlito B. Lebrilla +10 more
TL;DR: Comparison of HPLC-Chip/MS profiles from five different women revealed variations in milk oligosaccharide compositions, suggesting that Tandem MS in combination with exoglycosidase digestion provides unambiguous differentiation of structural isomers.
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Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation.
Riccardo G. LoCascio,Milady R. Niñonuevo,Samara L. Freeman,David A. Sela,Rudolf Grimm,Carlito B. Lebrilla,David A. Mills,J. Bruce German +7 more
TL;DR: Evidence is provided that these small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate a protective gut colonization in breast-fed newborns.
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A HUPO test sample study reveals common problems in mass spectrometry–based proteomics
Alexander W. Bell,Eric W. Deutsch,Catherine E. Au,Robert E. Kearney,Ron Beavis,Salvatore Sechi,Tommy Nilsson,John J.M. Bergeron,Thomas A. Beardslee,Thomas Chappell,Gavin Meredith,Peter J. Sheffield,Phillip Gray,Mahbod Hajivandi,Marshall Pope,Paul F. Predki,Majlinda Kullolli,Marina Hincapie,William S. Hancock,Wei Jia,Lina Song,Lei Li,Junying Wei,Bing Yang,Jinglan Wang,Wantao Ying,Yangjun Zhang,Yun Cai,Xiaohong Qian,Fuchu He,Helmut E. Meyer,Christian Stephan,Martin Eisenacher,Katrin Marcus,Elmar Langenfeld,Caroline May,Steve A. Carr,Rushdy Ahmad,Wenhong Zhu,Jeffrey W. Smith,Samir M. Hanash,Jason J. Struthers,Hong Wang,Qing Zhang,Yanming An,Radoslav Goldman,Elisabet Carlsohn,Sjoerd van der Post,Kenneth E. Hung,David A. Sarracino,Kenneth C. Parker,Bryan Krastins,Raju Kucherlapati,Sylvie Bourassa,Guy G. Poirier,Eugene A. Kapp,Heather Patsiouras,Robert L. Moritz,Richard J. Simpson,Benoit Houle,Sylvie Laboissiere,Pavel Metalnikov,Vivian Nguyen,Tony Pawson,Catherine C. L. Wong,Daniel Cociorva,John R. Yates,Michael J. Ellison,Ana Lopez-Campistrous,P. D. Semchuk,Yueju Wang,Peipei Ping,Giuliano Elia,Michael J. Dunn,Kieran Wynne,Angela K. Walker,John R. Strahler,Philip C. Andrews,Brian L. Hood,William L. Bigbee,Thomas P. Conrads,Derek Smith,Christoph H. Borchers,Gilles A. Lajoie,Sean C. Bendall,Kaye D. Speicher,David W. Speicher,Masanori Fujimoto,Kazuyuki Nakamura,Young Ki Paik,Sang Yun Cho,Min-Seok Kwon,Hyoung Joo Lee,Seul Ki Jeong,An Sung Chung,Christine A. Miller,Rudolf Grimm,Katy Williams,Craig A. Dorschel,Jayson A. Falkner,Lennart Martens,Juan Antonio Vizcaíno +101 more
TL;DR: Central analysis determined missed identifications, environmental contamination, database matching and curation of protein identifications as sources of problems in liquid chromatography–mass spectrometry–based proteomics.
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Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy
Fatima Ferreira,Christof Ebner,Bettina Kramer,Georg Casari,Peter Briza,Andreas J. Kungl,Rudolf Grimm,B. Jahn-Schmid,Heimo Breiteneder,Dietrich Kraft,Michael Breitenbach,Hans-Jörg Rheinberger,Otto Scheiner +12 more
TL;DR: Evaluated by site‐directed mutagenesis the contributions of individual amino acid residues/positions for IgE binding to Bet v 1, the major allergen of birch pollen, and found that IgEbinding toBet v 1 depended on at least six amino acid sequences, but conserved T cell activating capacity is necessary for immunomodulation.
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Development of an Annotated Library of Neutral Human Milk Oligosaccharides
TL;DR: Annotation of the neutral free oligosaccharides in milk is performed to develop a database for the rapid identification of oligosACcharide structures, which incorporates high performance nanoflow liquid chromatography and mass spectrometry for characterizing HMO structures.