Journal ArticleDOI
Microwave-assisted efficient conjugation of nanodiamond and paclitaxel
TLDR
Using a microwave energy to assist the functionalization of nanodiamond surface, the input of microwave energy is introduced to have approximately doubled grafted molecules per nanoparticle ofnanodiamond.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2015-05-15. It has received 11 citations till now. The article focuses on the topics: Nanodiamond & Surface modification.read more
Citations
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Journal ArticleDOI
Production, surface modification and biomedical applications of nanodiamonds: A sparkling tool for theranostics.
Hussain Tinwala,Sarika Wairkar +1 more
TL;DR: The versatile surface chemistry of NDs facilitates the conjugation with various functional groups and chemical moieties, which can be utilized for biomedical applications, which makes them the material of future interest in the field of medicine.
Journal ArticleDOI
Combinatorial nanodiamond in pharmaceutical and biomedical applications
TL;DR: This review gives an understanding of NDs in biomedical engineering and pharmaceuticals, focusing on the classified introduction of ND/drug complexes, and the diverse potential applications that can be obtained with chemical modification are presented.
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Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition.
Yu Wei Lin,Emmanuel Naveen Raj,Wei Siang Liao,Johnson Lin,Kuang Kai Liu,Ting Hua Chen,Hsiao Chun Cheng,Chi Ching Wang,Lily Yi Li,Chinpiao Chen,Jui-I Chao +10 more
TL;DR: It is demonstrated that the co-delivery of PTX and Cet by ND enhanced the effects of mitotic catastrophe and apoptosis in vitro and in vivo, which may be applied in the human CRC therapy.
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Fluorescent nanodiamonds engage innate immune effector cells: A potential vehicle for targeted anti-tumor immunotherapy.
Lorena P. Suarez-Kelly,Amanda Campbell,Isaac Rampersaud,Ambika Bumb,Min S. Wang,Jonathan P. Butchar,Susheela Tridandapani,Lianbo Yu,Arfaan A. Rampersaud,William E. Carson +9 more
TL;DR: Fluorescent nanodiamonds may serve as novel agents with "track and trace" capabilities to stimulate innate immune cell anti-tumor responses, especially as FNDs are amenable to surface-conjugation with immunomodulatory molecules.
References
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Journal ArticleDOI
Controlled microwave heating in modern organic synthesis.
TL;DR: This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.
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Bright Fluorescent Nanodiamonds: No Photobleaching and Low Cytotoxicity
TL;DR: The fluorescent nanodiamonds (FND) show no sign of photobleaching and can be taken up by mammalian cells with minimal cytotoxicity and the nanomaterial can have far-reaching biological applications.
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Are diamond nanoparticles cytotoxic
Amanda M. Schrand,Houjin Huang,Cataleya Carlson,John J. Schlager,Eiji Ōsawa,Saber M. Hussain, ,‡ and,Liming Dai +6 more
TL;DR: Assays of cell viability such as mitochondrial function (MTT) and luminescent ATP production showed that nanodiamonds were not toxic to a variety of cell types, and results suggest that nandiamonds could be ideal for many biological applications in a diverse range ofcell types.
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The biocompatibility of nanodiamonds and their application in drug delivery systems.
Ying Zhu,Jing Li,Wenxin Li,Yu Zhang,Xiafeng Yang,Nan Chen,Yanhong Sun,Yun Zhao,Chunhai Fan,Qing Huang +9 more
TL;DR: An adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging.
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Microwave chemistry: Out of the kitchen.
TL;DR: Designer microwave ovens that can heat reactants in record time are heralding a quiet revolution in chemical synthesis, and David Adam feels the heat.