Journal ArticleDOI
Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
Jifeng Liu,Jaekyoo Lee,Audra Dalton,Grace Bi,Libing Yu,Carmen M. Baldino,Eric McElory,Matthew Frank Brown +7 more
TLDR
In this article, a microwave-promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines was proposed for 2,3-disubstituted 3 H -quinazolin-4-ones.About:
This article is published in Tetrahedron Letters.The article was published on 2005-02-21. It has received 130 citations till now. The article focuses on the topics: One-pot synthesis.read more
Citations
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Journal ArticleDOI
The chemistry of recently isolated naturally occurring quinazolinone alkaloids
TL;DR: A concise account of the isolation, bioactivity, and synthesis of bioactive quinazolinone-based natural products for the period 1983-2005 is given in this paper.
Journal ArticleDOI
Controlled microwave heating in modern organic synthesis: highlights from the 2004–2008 literature
C. Oliver Kappe,Doris Dallinger +1 more
TL;DR: In this review, more than 220 published examples of microwave-assisted synthetic organic transformations from the 2004 to 2008 literature are discussed and more than 500 reaction schemes are presented in the Electronic Supplementary Material.
Journal ArticleDOI
In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.
TL;DR: A series of 2-methylaminobenzimidazole derivatives (1-11) synthesized by the reaction of 2-(chloromethyl)-1H-benzimidzole derivatives with primary aromatic amines showed good analgesic and anti-inflammatory activities.
Journal ArticleDOI
Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using KAl(SO4)2·12H2O as a reusable catalyst in water and ethanol
Minoo Dabiri,Peyman Salehi,Somayeh Otokesh,Mostafa Baghbanzadeh,Gholamreza Kozehgary,Ali A. Mohammadi +5 more
TL;DR: KAl(SO4)2·12H2O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as NH4 2CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields as mentioned in this paper.
Journal ArticleDOI
Recent advances in 4(3H)-quinazolinone syntheses
TL;DR: The current review article will briefly outline the new routes and strategies for the synthesis of valuable 4(3H)-quinazolinones.
References
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Journal ArticleDOI
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones
TL;DR: Although these compounds were markedly more potent as anticonvulsants when administered orally in mice and rats, they were also more neurotoxic, which resulted in marginal protective indices.
Journal ArticleDOI
Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists
Willard M. Welch,Frank E. Ewing,J. Huang,Frank S. Menniti,Martin J. Pagnozzi,Kristin Kelly,Patricia A. Seymour,Victor Guanowsky,S Guhan,M.R Guinn,D Critchett,John T. Lazzaro,Alan H. Ganong,Devries Keith Michael,T.L Staigers,Bertrand L. Chenard +15 more
TL;DR: Piriqualone was found to be an antagonist of AMPA receptors and (+)-38 (CP-465,022) was identified, a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.
Journal ArticleDOI
A Facile Synthesis of C2,N3-Disubstituted-4-quinazolone
TL;DR: In this article, a simple and efficient methodology for the synthesis of C2,N3-disubstituted-4 quinazolones from anilines and N-acylanthranilic acids was developed.
Journal ArticleDOI
Synthesis and Reactions of some 2-Vinyl-3H-quinazolin-4-ones
Anette Witt,Jan Bergman +1 more
TL;DR: A simple, high-yielding synthesis of 2-vinyl-3-H-quinazolin-4-one, 2-(1-chlorovinyl)-3H-quinazolinone-4, and 2-1-bromovinyl]-3-hexagonal-hexadecanequinazoline-4 was proposed in this article.