miR-532-3p promotes hepatocellular carcinoma progression by targeting PTPRT.
Yufeng Wang,Zhencun Yang,Liang Wang,Liankang Sun,Zhikui Liu,Qing Li,Bowen Yao,Tianxiang Chen,Cong Wang,Wei Yang,Qingguang Liu,Shaoshan Han +11 more
TLDR
It is demonstrated that miR-532-3p, which is frequently up-regulated in HCC, contributes to HCC cells mobility and proliferation through targeting PTPRT.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2019-01-01 and is currently open access. It has received 35 citations till now. The article focuses on the topics: PTPRT & Tumor progression.read more
Citations
More filters
Journal ArticleDOI
Circular RNA hsa_circRNA_103809 promoted hepatocellular carcinoma development by regulating miR-377-3p/FGFR1/ERK axis.
TL;DR: Novel regulatory signaling of hsa_circRNA_103809/miR‐377‐3p/FGFR1 axis is investigated, providing insights into hepatocellular carcinoma treatment from bench to clinic, and in vivo assays revealed hsa-circRNAs served as a tumor suppressor through downregulating FGFR1 in HCC.
Journal ArticleDOI
CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p).
TL;DR: In vitro assays showed that circRNA_103809 could inhibit cell proliferation and metastasis in breast cancer by sponging miR-532-3p, and circRNA-103809 might be a prospective target of breast cancer therapy.
Book ChapterDOI
The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment.
TL;DR: In this article, the authors focus on addressing two main questions: "How are oncogenes and/or tumor suppressor genes regulated by microRNAs?" and "Which other mechanisms in cancer cells are regulated by miRNAs?".
Journal ArticleDOI
Ectopic Expression of miR-532-3p Suppresses Bone Metastasis of Prostate Cancer Cells via Inactivating NF-κB Signaling.
Qingde Wa,Changye Zou,Lin Zhuoyuan,Sheng Huang,Xinsheng Peng,Chunxiao Yang,Dong Ren,Dongchu Xu,Yuanqing Guo,Zhuangwen Liao,Wang Bin,Hailan Hu,Shuai Huang,Peiheng He +13 more
TL;DR: It is reported thatmiR-532-3p was downregulated in PCa tissues with bone metastasis, and downexpression of miR- 532- 3p was significantly associated with Gleason grade and serum prostate-specific antigen (PSA) levels and predicted poorBone metastasis-free survival inPCa patients.
Journal ArticleDOI
MiR-124 sensitizes cisplatin-induced cytotoxicity against CD133+ hepatocellular carcinoma cells by targeting SIRT1/ROS/JNK pathway
TL;DR: It is demonstrated that overexpression of miR-124 sensitized cisplatin-induced cytotoxicity against CD133+ hepatocellular carcinoma cells by targeting SIRT1/ROS/JNK pathway.
References
More filters
Journal ArticleDOI
Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis.
Yufeng Wang,Zhikui Liu,Bowen Yao,Qing Li,Liang Wang,Cong Wang,Changwei Dou,Meng Xu,Qingguang Liu,Kangsheng Tu +9 more
TL;DR: Clinically, CASC2 underexpression and miR-367 overexpression were closely correlated with the metastasis-associated clinicopathologic features and it is concluded that the CASC 2/miR- 367/FBXW7 axis may be a ponderable and promising therapeutic target for HCC.
Journal ArticleDOI
The emerging role of exosome-derived non-coding RNAs in cancer biology.
Qing Fan,Liang Yang,Xiaodong Zhang,Xueqiang Peng,Shibo Wei,Dongming Su,Zhenhua Zhai,Xiangdong Hua,Hangyu Li +8 more
TL;DR: The promotion of tumor development by exosomal ncRNAs including chemotherapy resistance, metastasis and the prospective use of exosomes in cancer diagnosis and treatment are reviewed.
Journal ArticleDOI
Inhibiting TRK Proteins in Clinical Cancer Therapy
Allison M. Lange,Hui-Wen Lo +1 more
TL;DR: The current therapeutic trials for neoplasms involving NTKR gene alterations, as well as the promises and setbacks that are associated with targeting gene fusions, are summarized.
Journal ArticleDOI
Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma.
Zhikui Liu,Yufeng Wang,Changwei Dou,Meng Xu,Liankang Sun,Liang Wang,Bowen Yao,Qing Li,Wei Yang,Kangsheng Tu,Qingguang Liu +10 more
TL;DR: VASP was defined as an oncogene of HCC pathogenesis and metastasis with the potential to serve as a prognostic biomarker after a variety of hypoxia-induced molecular mechanisms contributed to the upregulation of VASP at transcriptional and post-transcriptional levels.
Journal ArticleDOI
MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1
Changwei Dou,Yufeng Wang,Chao Li,Zhikui Liu,Yuli Jia,Qing Li,Wei Yang,Yingmin Yao,Qingguang Liu,Kangsheng Tu +9 more
TL;DR: In this paper, the mean level of microRNA-212 in hepatocellular carcinoma (HCC) tissues was significantly lower than that in matched tumor-adjacent tissues, and the expression of miR-212 was obviously reduced in HCC cell lines as compared with a nontransformed hepatic cell line.