Journal ArticleDOI
Modelling of crystallization process and optimization of the cooling strategy
TLDR
In this article, an optimal cooling strategy is obtained through simulation and compared to linear and natural cooling strategies, which showed uniform and large crystal size distribution while products from the other two strategies contained significant amount of fine particles.Abstract:
To obtain a uniform and large crystal in seeded batch cooling crystallization, the cooling strategy is very important. In this study, an optimal cooling strategy is obtained through simulation and compared to linear and natural cooling strategies. A model for a crystallization process in a batch reactor is constructed by using population balance equation and material balance for solution concentration, and a prediction model for meta-stable limit is formulated by the dynamic meta-stable limit approach. Based on this model, an optimal cooling strategy is obtained using genetic algorithm with the objective function of minimizing the unwanted nucleation and maximizing the crystal growth rate. From the simulation results, the product from the optimal cooling strategy showed uniform and large crystal size distribution while products from the other two strategies contained significant amount of fine particles.read more
Citations
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Journal ArticleDOI
Model-Based Systematic Design and Analysis Approach for Unseeded Combined Cooling and Antisolvent Crystallization (CCAC) Systems
Yang Yang,Zoltan K. Nagy +1 more
TL;DR: In this paper, a model-based systematic analysis and design approach for unseeded combined cooling and antisolvent crystallization (CCAC) processes has been proposed and evaluated for the crystallization of aspirin in ethanol-water mixture.
Journal ArticleDOI
Application of Internal Seeding and Temperature Cycling for Reduction of Liquid Inclusion in the Crystallization of RDX
TL;DR: In this article, an internal seeding method combined with temperature cycling was applied to suppress liquid inclusion in cyclotrimethylene trinitramine (RDX) cooling crystallization.
Journal ArticleDOI
Optimization and control of crystal shape and size in protein crystallization process
TL;DR: Since tracking an optimum temperature or supersaturation trajectory can be easily implemented by manipulating the coolant flowrate in the reactor jacket, the methodology provides a feasible closed-loop mechanism for protein crystal shape tailoring and control.
Journal ArticleDOI
Solubility Measurement and Thermodynamic Modeling of Benzoic Acid in Monosolvents and Binary Mixtures
Kadakanchi Sandeepa,Kadakanchi Sandeepa,Kosuru Ravi Kumar,T. S. V. R. Neeharika,Bankupalli Satyavathi,Prathap Kumar Thella +5 more
TL;DR: In this paper, the solid-liquid equilibrium of benzoic acid has been determined in six monosolvents (tributyl phosphate, diacetone alcohol, methyl-n-propyl ketone, methyl acetate, amyl acetate and isooctane).
Journal ArticleDOI
Impact of seed loading ratio on the growth kinetics of mono-ammonium phosphate under isothermal batch crystallization
TL;DR: In this paper, the effect of seed load ratio on the growth kinetics of Mono-ammonium phosphate (MAP) under isothermal batch crystallization was investigated quantitatively, and a direct parameter estimation method was proposed and applied to extract the growth kinetic parameters from a simple crystallization model using our experimental solution concentration decline data.
References
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BookDOI
Adaptation in Natural and Artificial Systems: An Introductory Analysis with Applications to Biology, Control and Artificial Intelligence
TL;DR: Initially applying his concepts to simply defined artificial systems with limited numbers of parameters, Holland goes on to explore their use in the study of a wide range of complex, naturally occuring processes, concentrating on systems having multiple factors that interact in nonlinear ways.
Journal ArticleDOI
Metastable zone-width of some aqueous solutions
TL;DR: In this article, the metastable zone-widths of 25 different systems and their dependence on the cooling rate, the temperature and the presence or absence of crystals are reported and the results are discussed.
Journal ArticleDOI
A multi-crossover genetic approach to multivariable PID controllers tuning
TL;DR: A modified crossover formula in genetic algorithms (GAs) is proposed, and this method is applied into the design of multivariable PID control systems for deriving optimal or near optimal control gains such that the definition of integrated absolute error (IAE) is minimized as much as possible.
Journal ArticleDOI
On-line optimal control of a seeded batch cooling crystallizer
G.P. Zhang,Sohrab Rohani +1 more
TL;DR: In this paper, an on-line optimal control methodology is developed for the optimal quality control of a seeded batch cooling crystallizer process, where an extended Kalman filter is successfully implemented to predict seven unmeasured state variables based on three measurements in the batch process.
Journal ArticleDOI
Multi-objective optimization of seeded batch crystallization processes
TL;DR: In this article, a multi-objective approach was adopted for optimization of a batch cooling crystallizer for best process operation, and the solution of various optimal control problems for a seeded batch crystallizer within a multiobjective framework was presented.