Modulation of rotavirus severe gastroenteritis by the combination of probiotics and prebiotics
Guadalupe González-Ochoa,Lilian Flores-Mendoza,Ramona Icedo-García,Ricardo Gomez-Flores,Patricia Tamez-Guerra +4 more
TLDR
In this article, the rotavirus pathogenesis and immunity was discussed, and probiotics such as Lactobacillus and Bifidobacterium species in combination with prebiotics have been associated with the prevention or modulation of rotivirus severe gastroenteritis.Abstract:
Annual mortality rates due to infectious diarrhea are about 2.2 million; children are the most vulnerable age group to severe gastroenteritis, representing group A rotaviruses as the main cause of disease. One of the main factors of rotavirus pathogenesis is the NSP4 protein, which has been characterized as a viral toxin involved in triggering several cellular responses leading to diarrhea. Furthermore, the rotavirus protein NSP1 has been associated with interferon production inhibition by inducing the degradation of interferon regulatory factors IRF3, IRF5, and IRF7. On the other hand, probiotics such as Bifidobacterium and Lactobacillus species in combination with prebiotics such as inulin, HMO, scGOS, lcFOS have been associated with improved generalized antiviral response and anti-rotavirus effect by the reduction of rotavirus infectivity and viral shedding, decreased expression of NSP4 and increased levels of specific anti-rotavirus IgAs. Moreover, these probiotics and prebiotics have been related to shorter duration and severity of rotavirus diarrhea, to the prevention of infection and reduced incidence of reinfections. In this review we will discuss in detail about the rotavirus pathogenesis and immunity, and how probiotics such as Lactobacillus and Bifidobacterium species in combination with prebiotics have been associated with the prevention or modulation of rotavirus severe gastroenteritis.read more
Citations
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Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview.
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Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic
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Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis.
Stephen B. Freedman,Sarah Williamson-Urquhart,Ken J. Farion,Serge Gouin,Andrew R. Willan,Naveen Poonai,Katrina F. Hurley,Philip M. Sherman,Yaron Finkelstein,Bonita E. Lee,Xiao-Li Pang,Linda Chui,David Schnadower,Jianling Xie,Marc H. Gorelick,Suzanne Schuh +15 more
TL;DR: In children who presented to the emergency department with gastroenteritis, twice‐daily administration of a combined L. rhamnosus–L.
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Probiotics as an alternative antimicrobial therapy: Current reality and future directions
Diego Romário Silva,Janaina de Cássia Orlandi Sardi,Nayla de Souza Pitangui,Sindy Magri Roque,Andréa Cristina Barbosa da Silva,Pedro Luiz Rosalen,Pedro Luiz Rosalen +6 more
TL;DR: There remains no consensus or standardization on the development of delivery systems and on the application of probiotic formulations for antimicrobial therapy, so further bioguided studies and clinical trials are needed to address the existing gaps in the knowledge.
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