Molecular Analysis of the BCL-3 Locus at Chromosome 17q22 in B-Cell Neoplasms
Takahiro Yano,Christian A. Sander,Rafael Andrade,Charlotte E. Gauwerky,Carlo M. Croce,Dan L. Longo,Elaine S. Jaffe,Mark Raffeld +7 more
TLDR
Although the preferential involvement of BCL-3 alterations in a small subset of follicular lymphomas that transform suggests a possible link between these abnormalities and progression, further studies are needed to ensure that these alterations are biologically relevant and not simply a manifestation of genomic instability.About:
This article is published in Blood.The article was published on 1993-09-15 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Follicular lymphoma & MYC Gene Rearrangement.read more
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Mutations in the NF-kappaB signaling pathway: implications for human disease.
G Courtois,Thomas D. Gilmore +1 more
TL;DR: This review describes human diseases in which mutations in the components of the core NF-κB signaling pathway have been implicated and discusses the molecular mechanisms by which these alterations in NF-σB signaling are likely to contribute to the disease pathology.
Journal ArticleDOI
p53 mutation is associated with progression in follicular lymphomas
Christian A. Sander,Takahiro Yano,Helen M. Clark,Cynthia Harris,Dan L. Longo,Elaine S. Jaffe,Mark Raffeld +6 more
TL;DR: Serial biopsies from 34 patients with follicular lymphomas that underwent histologic transformation, for abnormalities of the p53 tumor suppressor gene by a combination of immunohistochemistry, single strand conformation polymorphism analysis (SSCP), and sequencing suggest that p53 positive low-grade lymphomas are at risk for progression and that in this subset, aggressive therapy may be warranted.
Journal ArticleDOI
The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation.
TL;DR: In several pathogenic conditions components of the NF-κB system are deregulated and could thus present potential diagnostic probes or targets for therapeutic intervention.
Book ChapterDOI
Apoptosis and cancer chemotherapy.
TL;DR: There appears to be a heavy selection pressure for genetic changes that inhibit apoptosis in cancer cells, and inhibition of apoptosis may represent a new form of drug resistance in cancer treatment.
Journal ArticleDOI
Search for rearrangements and/or allelic loss of the fas/APO-1 gene in 101 human lymphomas.
TL;DR: Fas/APO-1 alterations do occur in human lymphomas, although at a relatively low frequency, and Ipr mouse mutants, which present with a generalized lymphoproliferative disease, were shown to exhibit alterations of fas/APS-1 structure and expression.
References
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Journal ArticleDOI
Involvement of the bcl-2 gene in human follicular lymphoma
TL;DR: Chromosome 18-specific DNA probes for the areas flanking the breakpoints also detected RNA transcripts 6 kilobases in length in various cell types, and the gene coding for these transcript seems to be interrupted in most cases of follicular lymphomas carrying the t(14;18) chromosomal translocation.
Journal ArticleDOI
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18
Ajay Bakhshi,Ajay Bakhshi,Jane P. Jensen,Jane P. Jensen,Paula L. Goldman,Paula L. Goldman,John J. Wright,John J. Wright,O. Wesley McBride,O. Wesley McBride,Alan L. Epstein,Alan L. Epstein,Stanley J. Korsmeyer,Stanley J. Korsmeyer +13 more
TL;DR: The t(14;18)(q32;q21) chromosomal translocation present in over 60% of human follicular lymphomas is characterized and an unexpected rearrangement of an Ig heavy-chain gene is exploited to clone the chromosomal breakpoint.
Journal ArticleDOI
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Gianluca Gaidano,P. Ballerini,Jerry Z. Gong,Giorgio Inghirami,Antonino Neri,Elizabeth W. Newcomb,Ian T. Magrath,Daniel M. Knowles,Riccardo Dalla-Favera +8 more
TL;DR: It is suggested that p53 may play a role in tumor progression in B-cell chronic lymphocytic leukemia and the presence of both p53 loss/inactivation and c-myc oncogene activation may be important in the pathogenesis of Burkitt lymphoma and its leukemic form L3-type B- cell acute lymphoblastic leukemia.
Journal ArticleDOI
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18).
TL;DR: The transgenic mice provide an animal model for tumour progression in t(14; 18) lymphoma and show that prolonged B-cell life increases tumour incidence, and the long latency, progression from polyclonal to monoclonal disease, and histological conversion are all suggestive of secondary changes.
Journal ArticleDOI
Translocation and Rearrangements of the c-myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas
TL;DR: It is shown in this study that the c- myc locus is rearranged in 5 out of 15 cell lines from patients with undifferentiated B-cell lymphomas, and that the rearrangement involves a region at the 5' side of an apparently intact c-myc gene.