Molecular cloning of a novel melanocortin receptor.
Ira Gantz,Yoshitaka Konda,Takao Tashiro,Yoshimasa Shimoto,Hiroto Miwa,Gerd Munzert,Stanley J. Watson,John DelValle,T Yamada +8 more
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TLDR
The molecular cloning and pharmacologic characterization of a third member of this receptor family is reported, which characterizes it as an MSH receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH.About:
This article is published in Journal of Biological Chemistry.The article was published on 1993-04-15 and is currently open access. It has received 715 citations till now. The article focuses on the topics: Melanocortin 3 receptor & Melanocortin.read more
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Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Dennis Huszar,Catherine A. Lynch,Victoria Fairchild-Huntress,Judy H. Dunmore,Qing Fang,Lucy R Berkemeier,Wei Gu,Robert A. Kesterson,Bruce A. Boston,Roger D. Cone,Françoise J. Smith,L. Arthur Campfield,Paul Burn,Frank W. Lee +13 more
TL;DR: The data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R.
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Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
Michael Martin Ollmann,Brent D. Wilson,Brent D. Wilson,Ying-kui Yang,Ying-kui Yang,Julie A. Kerns,Julie A. Kerns,Yanru Chen,Yanru Chen,Ira Gantz,Ira Gantz,Gregory S. Barsh,Gregory S. Barsh +12 more
TL;DR: Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation and is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling.
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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
TL;DR: The authors' data show that melanocortinergic neurons exert a tonic inhibition of feeding behaviour, and chronic disruption of this inhibitory signal is a likely explanation of the agouti obesity syndrome.
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Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
TL;DR: Melanogenesis is a highly structured system, active since early embryogenesis and capable of superselective functional regulation that may reach down to the cellular level represented by single melanocytes, and its significance extends beyond the mere assignment of a color trait.
Journal Article
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
TL;DR: In this article, cyclic melanocortin analogues were identified that are potent agonists or antagonists of the neural MC3 and MC4 receptors, thus explaining the inhibitory effect of agouti on eumelanin pigment synthesis.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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The cloning of a family of genes that encode the melanocortin receptors
TL;DR: The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned and define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.
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Selective amplification and cloning of four new members of the G protein-coupled receptor family.
Frédérick Libert,Marc Parmentier,Anne Lefort,Christiane Dinsart,J. Van Sande,Carine Maenhaut,Marie-Jeanne Simons,Jacques Emile Dumont,Gilbert Vassart +8 more
TL;DR: An approach based on the polymerase chain reaction has been devised to clone new members of the family of genes encoding guanosine triphosphate-binding protein (G protein)-coupled receptors, suggesting that they are members of a new subfamily of receptors with a very short nonglycosylated amino-terminal extension.
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Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.
TL;DR: The cloned cDNA encodes a 317 amino acid protein with transmembrane topography characteristics of a G‐protein‐coupled receptor, but it does not show striking similarity to already published sequences of other G‐ proteins of the melanotropin receptor family.