Molecular mechanism of antimicrobial peptides : The origin of cooperativity
TLDR
A mechanism to explain the cooperativity exhibited by the activities of antimicrobial peptides, namely, a non-linear concentration dependence characterized by a threshold and a rapid rise to saturation as the concentration exceeds the threshold is proposed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2006-02-28 and is currently open access. It has received 435 citations till now. The article focuses on the topics: Peptide binding & Alamethicin.read more
Citations
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Designing antimicrobial peptides: form follows function
TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
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The Multifaceted Functions of Neutrophils
TL;DR: Primordial neutrophil functions are discussed, and more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation is presented.
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Cooperativity in Noncovalent Interactions.
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NETs: a new strategy for using old weapons
TL;DR: Neutrophil Extracellular Traps may contribute to microbial containment by forming a physical barrier and a scaffold, to enhance antimicrobial synergy while minimizing damage to host tissues.
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Antimicrobial peptides: key components of the innate immune system
TL;DR: An overview of cationic antimicrobial peptides, origin, structure, functions, and mode of action of AMPs, which are highly expressed and found in humans, as well as a brief discussion about widely abundant, well characterized AMPs in mammals.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Elastic Properties of Lipid Bilayers: Theory and Possible Experiments
TL;DR: A theory of the elasticity of lipid bilayers is proposed and it is argued that in the case of vesicles (= closed bilayer films) the only elasticity controlling nonspherical shapes is that of curvature.
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Structure of lipid bilayers
TL;DR: The uncertainty in structural results for lipid bilayers is being reduced and best current values are provided for bilayers of five lipids.
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Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
TL;DR: A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis and appears to represent a previously unrecognized class of vertebrate antimicrobial activities.
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Effect of Chain Length and Unsaturation on Elasticity of Lipid Bilayers
TL;DR: To test this hypothesis, peak-to-peak headgroup thicknesses h(pp) of bilayers were obtained from x-ray diffraction of multibilayer arrays at controlled relative humidities and showed that poly-cis unsaturated chain bilayers are thinner and more flexible than saturated/monounsaturated chain Bilayers.