Molecular mechanisms of ovulation: co-ordination through the cumulus complex
Reads0
Chats0
TLDR
This review focuses on the recent advances in understanding of molecular mechanisms that commence after the gonadotrophin surge and culminate with release of the oocyte.Abstract:
Successful ovulation requires that developmentally competent oocytes are released with appropriate timing from the ovarian follicle. Somatic cells of the follicle sense the ovulatory stimulus and guide resumption of meiosis and release of the oocyte, as well as structural remodelling and luteinization of the follicle. Complex intercellular communication co-ordinates critical stages of oocyte maturation and links this process with release from the follicle. To achieve these outcomes, ovulation is controlled through multiple inputs, including endocrine hormones, immune and metabolic signals, as well as intrafollicular paracrine factors from the theca, mural and cumulus granulosa cells and the oocyte itself. This review focuses on the recent advances in understanding of molecular mechanisms that commence after the gonadotrophin surge and culminate with release of the oocyte. These mechanisms include intracellular signalling, gene regulation and remodelling of tissue structure in each of the distinct ovarian compartments. Most critical ovulatory mediators exert effects through the cumulus cell complex that surrounds and connects with the oocyte. The convergence of ovulatory signals through the cumulus complex co-ordinates the key mechanistic processes that mediate and control oocyte maturation and ovulation.read more
Citations
More filters
Journal ArticleDOI
Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
TL;DR: A new perspective on oocyte-CC interactions is improving knowledge of the processes regulating oocyte quality, which is likely to have a number of applications, including improving the efficiency of clinical IVM and thereby providing new options for the treatment of infertility.
Journal ArticleDOI
Contemporary genetic technologies and female reproduction
B. C. J. M. Fauser,Klaus Diedrich,Philippe Bouchard,Francisco Domínguez,M. Matzuk,Steve Franks,S. Hamamah,Carlos Simón,Paul Devroey,Diego Ezcurra,Colin M. Howles +10 more
TL;DR: The way forward in advancing the knowledge of genes involved in reproduction was considered to be through genome-wide association studies involving large numbers of patients, and establishing international collaboration is required to enable the application of such technologies in sufficient numbers of customers.
Journal ArticleDOI
Reactive oxygen species are indispensable in ovulation
TL;DR: Evidence is provided that ovarian production of ROS is an essential preovulatory signaling event, most probably transiently triggered by LH, and administration of broad-range scavengers of oxidative species into the ovarian bursa of mice significantly reduced the rate of ovulation.
Journal ArticleDOI
Could oxidative stress influence the in-vitro maturation of oocytes?
TL;DR: Future studies profiling the oxidative stress status of the oocyte may permit not only the formulation of a superior IVM medium that maintains an adequate pro-/antioxidant balance, but also the identification of predictors of oocyte quality.
Journal ArticleDOI
Hormonal regulation of microrna expression in periovulatory mouse mural granulosa cells
TL;DR: The following studies are the first to describe the extent of miRNA expression within ovarian granulosa cells and theFirst to demonstrate that LH/hCG regulates the expression of select miRNAs, which affect posttranscriptional gene regulation within these cells.
References
More filters
Book
The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
Journal ArticleDOI
Erk and p38 mapk-activated protein kinases: a family of protein kinases with diverse biological functions
Philippe P. Roux,John Blenis +1 more
TL;DR: The identities of the MK substrates indicate that they play important roles in diverse biological processes, including mRNA translation, cell proliferation and survival, and the nuclear genomic response to mitogens and cellular stresses.
Journal ArticleDOI
MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes
Thiennu H. Vu,J. Michael Shipley,Gabriele Bergers,Joel E. Berger,Jill A. Helms,Douglas Hanahan,Steven D. Shapiro,Robert M. Senior,Zena Werb +8 more
TL;DR: Transplantation of wild-type bone marrow cells rescues vascularization and ossification in gelatinase B-null growth plates, indicating that these processes are mediated by gelatinaseB-expressing cells of bone marrow origin, designated chondroclasts.
Journal ArticleDOI
Growth differentiation factor-9 is required during early ovarian folliculogenesis
TL;DR: Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised, and GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo.
Journal ArticleDOI
Multiple female reproductive failures in cyclooxygenase 2-deficient mice.
Hyunjung Jade Lim,Bibhash C. Paria,Sanjoy K. Das,Joseph E. Dinchuk,Robert Langenbach,James M. Trzaskos,Sudhansu K. Dey +6 more
TL;DR: It is demonstrated herein that the targeted disruption of COX-2, but notCOX-1, in mice produces multiple failures in female reproductive processes that include ovulation, fertilization, implantation, and decidualization.