Monoallelic expression of MAO-A in skin fibroblasts
Niklas Nordquist,Lars Oreland +1 more
TLDR
The results show that the MAO-A gene has mono-allelic expression in primary clonal cell cultures, which could have important implications for understanding traits that display gender differences.Abstract:
X chromosome inactivation in mammalian females occurs early in embryonic development and renders most genes on the inactive X chromosome transcriptionally silenced. As a consequence, females will display an X chromosomal parent-of-origin mosaicism with regard to which parental allele that is expressed. Some genes however, escape inactivation and will therefore be expressed from both alleles. In this study we have investigated if the X-linked MAO-A gene have bi- or mono-allelic expression. This information would indicate whether or not MAO-A gene dosage could potentially explain the observed gender differences that show functional connections to the serotonin system, such as aggression and impulsiveness. To investigate the X inactivation status of MAO-A we have used primary clonal cell cultures, on which allelic expression was assessed with RFLP analysis. Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences.read more
Citations
More filters
Journal ArticleDOI
The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour.
TL;DR: In this article, Antisocial behaviour has been associated with polymorphic variants in candidate genes and recently also gene-environmental interaction models have been presented, and it has been suggested...
Journal ArticleDOI
Effects of age and MAOA genotype on the neural processing of social rejection
Catherine L. Sebastian,Jonathan P. Roiser,Geoffrey Tan,Essi Viding,Nicholas W. Wood,Sarah-Jayne Blakemore +5 more
TL;DR: The data suggest continued functional development of the circuitry underlying the processing of social rejection between adolescence and adulthood, and show that the effects of MAOA genotype on neural responses may vary with age.
Journal ArticleDOI
Serotonin pathway gene-gene and gene-environment interactions influence behavioral stress response in infant rhesus macaques.
Erin L. Kinnally,Genesio M. Karere,Leslie A. Lyons,Sally P. Mendoza,William A. Mason,John P. Capitanio +5 more
TL;DR: The combined influence of two serotonin pathway polymorphisms and species-atypical, and possibly adverse, rearing on two dimensions of behavioral stress response in infant rhesus macaques is investigated.
Journal ArticleDOI
Genetics of Depression: An Overview of the Current Science
Betty L. Elder,Victoria Mosack +1 more
TL;DR: Recent literature related to the genetics of MDD is synthesized and the genetic pathways for major depression are illustrated.
Book ChapterDOI
Monoamine Oxidases and Flavin-Containing Monooxygenases
J.R. Cashman,M.S. Motika +1 more
TL;DR: A view of the balance between these dual roles of MAO and FMO flavoenzymes is presented, which has largely been associated with detoxication of chemicals to more polar and generally less toxic metabolites that are usually efficiently excreted.
References
More filters
Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
X-inactivation profile reveals extensive variability in X-linked gene expression in females
TL;DR: A comprehensive X-inactivation profile of the human X chromosome is presented, representing an estimated 95% of assayable genes in fibroblast-based test systems, and suggests a remarkable and previously unsuspected degree of expression heterogeneity among females.
Journal ArticleDOI
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.
Journal ArticleDOI
The developmental role of serotonin: news from mouse molecular genetics
TL;DR: New genetic models that target the serotonin system show that transient alterations in serotonin homeostasis cause permanent changes to adult behaviour and modify the fine wiring of brain connections.
Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.