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Motion artifact removal and signal enhancement to achieve in vivo dynamic full field OCT

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TLDR
In this article, a filtering procedure based on singular value decomposition was proposed to remove artifacts arising from sample motion during dynamic full field OCT acquisitions, which succeeded in removing artifacts created by environmental noise from data acquired in a clinical setting, including in vivo data.
Abstract
We present a filtering procedure based on singular value decomposition to remove artifacts arising from sample motion during dynamic full field OCT acquisitions. The presented method succeeded in removing artifacts created by environmental noise from data acquired in a clinical setting, including in vivo data. Moreover, we report on a new method based on using the cumulative sum to compute dynamic images from raw signals, leading to a higher signal to noise ratio, and thus enabling dynamic imaging deeper in tissues.

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Imaging and quantifying ganglion cells and other transparent neurons in the living human retina

TL;DR: In this paper, the authors show that singly scattered light actually carries substantial information that reveals GC somas, axons, and other retinal neurons and permits their quantitative analysis.
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Present Application and Perspectives of Organoid Imaging Technology

TL;DR: In this article , the principle, advantages and disadvantages of imaging technologies that have been applied in organoid research are introduced, as well as an overview of prospective technologies for organoid imaging.
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Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography

TL;DR: In this paper , a dynamic optical coherence tomography (OCT) system was used for label-free metabolic imaging of non-alcoholic fatty liver disease (NAFLD) mouse liver.
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Characterization and Analysis of Retinal Axial Motion at High Spatiotemporal Resolution and Its Implication for Real-Time Correction in Human Retinal Imaging

TL;DR: It is demonstrated that although breath-holding can help decrease large-and-slow drifts, it increases small- and-fast fluctuations, which is not ideal when motion compensation is desired, and a loop rate of 1.2 kHz is ideal to achieve 100% robust clinical in-vivo retinal imaging.
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Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography

TL;DR: Results imply that volumetric LIV imaging is useful for visualizing and assessing NAFLD abnormalities, and suggest that label-free metabolic imaging of non-alcoholic fatty liver disease (NAFLD) mouse liver is demonstrated ex vivo by dynamic optical coherence tomography (OCT).
References
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Journal ArticleDOI

Optical coherence tomography

TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
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Trainable Weka Segmentation: a machine learning tool for microscopy pixel classification.

TL;DR: The Trainable Weka Segmentation (TWS), a machine learning tool that leverages a limited number of manual annotations in order to train a classifier and segment the remaining data automatically, is introduced.
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A review of optical coherence tomography angiography (OCTA).

TL;DR: OCTA is quick and non-invasive, and provides volumetric data with the clinical capability of specifically localizing and delineating pathology along with the ability to show both structural and blood flow information in tandem, its current limitations include a relatively small field of view.
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Spatiotemporal Clutter Filtering of Ultrafast Ultrasound Data Highly Increases Doppler and fUltrasound Sensitivity

TL;DR: The singular value decomposition (SVD) takes benefits of the different features of tissue and blood motion in terms of spatiotemporal coherence and strongly outperforms conventional clutter rejection filters based on high pass temporal filtering.
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