Journal ArticleDOI
Mu-opioid receptor activation promotes in vitro and in vivo tumor growth in head and neck squamous cell carcinoma.
Aysegul Gorur,Miguel Patino,Hideaki Takahashi,German Corrales,Curtis R. Pickering,Frederico O. Gleber-Netto,Jeffrey N. Myers,Juan P. Cata +7 more
TLDR
In this paper, the role of mu-opioid receptor (MOR) activation in head and neck squamous cell carcinoma (HNSCC) progression was examined in in vitro and in vivo experiments.About:
This article is published in Life Sciences.The article was published on 2021-04-27. It has received 7 citations till now. The article focuses on the topics: Head and neck squamous-cell carcinoma & In vivo.read more
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Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)
TL;DR: The biological consequences of surgery of Oral Squamous Cell Carcinoma, the most frequent form of primary head and neck tumors, are reviewed and the recent trials examining neoadjuvant immunotherapy for OSCC illustrate the therapeutic opportunities offered by the perioperative period.
Journal ArticleDOI
Perioperative pain, analgesics and cancer-related outcomes: where do we stand?
TL;DR: In this article , the authors focus on the pharmacological management of cancer-related pain and offer an overview regarding the use of these medications perioperatively and the cancer outcomes.
Journal ArticleDOI
Opioid use, misuse, and abuse: a narrative review about interventions to reduce opioid consumption and related adverse events in the perioperative setting
TL;DR: The history, current trends, and new directions in perioperative opioid prescription in an unbiased manner are summarized in this paper , where the authors summarize the history and current trends of opioid prescription.
Journal ArticleDOI
Perioperative pain, analgesics and cancer-related outcomes: where do we stand?
TL;DR: In this article, the authors focus on the pharmacological management of cancer-related pain and offer an overview regarding the use of these medications perioperatively and the cancer outcomes.
Journal ArticleDOI
Mu opioid receptor mRNA overexpression predicts poor prognosis among 18 common solid cancers: A pan-cancer analysis
TL;DR: In this paper , the authors conducted a pan-cancer genomic analysis to investigate the prognostic features of Mu opioid receptor (MOR) mRNA expression across 18 primary solid cancers, and found that positive MOR mRNA expression was associated with more advanced stage of T (adjusted Odds ratio [OR], 1.176; 95% confidence interval [CI],1.022-1.354; P=0.024), M (adjusted OR, 1.548, 95% CI, 1095-2.
References
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Molecular Mechanisms and Regulation of Opioid Receptor Signaling
TL;DR: In the current review, recent advances in the delineation basis for the multiple opioid receptor signaling, and their regulation at multiple levels are examined.
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Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
Tommaso Costa,Albert Herz +1 more
TL;DR: It is shown that for a member of this family of receptors (delta opioid receptors in membranes of NG108-15 neuroblastoma-glioma cells), two types of competitive antagonists can be distinguished and one has no intrinsic activity and the second can inhibit GTPase and thus exhibits negative intrinsic activity.
Journal Article
Morphine Stimulates Angiogenesis by Activating Proangiogenic and Survival-promoting Signaling and Promotes Breast Tumor Growth
Kalpna Gupta,Smita Kshirsagar,Liming Chang,Robert E. Schwartz,Ping-Yee Law,Douglas Yee,Robert P. Hebbel +6 more
TL;DR: It is shown that morphine in clinically relevant doses promotes tumor neovascularization in a human breast tumor xenograft model in mice leading to increased tumor progression, indicating that clinical use of morphine could potentially be harmful in patients with angiogenesis-dependent cancers.
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Basic opioid pharmacology: an update
Hasan Pathan,John P. Williams +1 more
TL;DR: Most clinically relevant opioid analgesics bind to MOP receptors in the central and peripheral nervous system in an agonist manner to elicit analgesia.