Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner.
David P. Cormode,Salim Si-Mohamed,Daniel Bar-Ness,Monica Sigovan,Pratap C. Naha,Joëlle Balegamire,Franck Lavenne,Philippe Coulon,Ewald Roessl,Matthias Bartels,Michal Rokni,Ira Blevis,Loic Boussel,Philippe Douek +13 more
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A clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.Abstract:
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents' concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.read more
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Photon-counting CT: Technical Principles and Clinical Prospects.
TL;DR: The authors will explain the technical principles of photon-counting CT in nonmathematical terms for radiologists and clinicians to create opportunities for quantitative imaging relative to current CT technology.
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The evolution of image reconstruction for CT—from filtered back projection to artificial intelligence
TL;DR: A concise look at the overall evolution of CT image reconstruction and its clinical implementations is taken, finding IR is essential for photon-counting CT, phase-contrast CT, and dark-field CT.
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Photon-counting Detector CT: System Design and Clinical Applications of an Emerging Technology
Shuai Leng,Michael R. Bruesewitz,Shengzhen Tao,Kishore Rajendran,Ahmed F. Halaweish,Norbert G. Campeau,Joel G. Fletcher,Cynthia H. McCollough +7 more
TL;DR: PCD technology and its use for in vivo high-spatial-resolution multienergy CT imaging is discussed, and examples with phantom, animal, and patient studies are provided.
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Photon-counting CT review
TL;DR: An overview of the principles of photon-counting detector CT, of potential clinical benefits and limitations, and of the experience gained so far in pre-clinical installations are given.
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TL;DR: A CT system with energy detection capabilities is presented, which was used to demonstrate the feasibility of quantitative K-edge CT imaging experimentally and derive a phenomenological model for the detector response and the energy bin sensitivities.