Journal ArticleDOI
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs.
Rajesh Krishna,Lawrence D. Mayer +1 more
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TLDR
In this paper, a review of P-glycoprotein (P-GP)-mediated pharmacokinetic interactions is presented, where the relevance of these drug transport proteins in the context of pharmacokinetics implications (drug absorption, distribution, clearance, and interactions) is discussed.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2000-10-01. It has received 1046 citations till now. The article focuses on the topics: Multiple drug resistance.read more
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Molecular mechanisms of drug resistance
TL;DR: The signalling pathways involved in regulating tumour cell response to chemotherapy more completely than ever before are characterized, which will facilitate the future development of rational combined chemotherapy regimens, in which the newer targeted therapies are used in combination with cytotoxic drugs to enhance chemotherapy activity.
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Nanoparticles - A Review
V J Mohanraj,Y Chen +1 more
TL;DR: Various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes are reviewed.
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Nanotechnology Applications in Cancer
TL;DR: Developments in bioaffinity nanoparticle probes for molecular and cellular imaging, targeted nanoparticle drugs for cancer therapy, and integrated nanodevices for early cancer detection and screening raise exciting opportunities for personalized oncology in which genetic and protein biomarkers are used to diagnose and treat cancer based on the molecular profiles of individual patients.
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Amphiphilic block copolymers for drug delivery
TL;DR: The purpose of this minireview is to provide a concise, yet detailed, introduction to the use of ABCs and polymeric micelles as delivery agents as well as to highlight current and past work in this area.
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Journal ArticleDOI
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Michael M. Gottesman,Ira Pastan +1 more
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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.
TL;DR: Observations on the molecular basis of pleiotropic drug resistance are interpreted in terms of a model wherein certain surface glycoproteins control drug permeation by modulating the properties of hydrophobic membrane regions.
Journal ArticleDOI
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
TL;DR: It is demonstrated that an oncogene, specifically the adenovirus E1A gene, can sensitize fibroblasts to apoptosis induced by ionizing radiation, 5-fluorouracil, etoposide, and adriamycin, and the involvement of p53 in the apoptotic response suggests a mechanism whereby tumor cells can acquire cross-resistance to anticancer agents.
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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Susan P.C. Cole,Gabu Bhardwaj,James H. Gerlach,J. E. Mackie,Caroline E. Grant,Kurt C. Almquist,Alistair J. Stewart,Ebba U. Kurz,A. M. V. Duncan,Roger G. Deeley +9 more
TL;DR: Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.
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p53 is required for radiation-induced apoptosis in mouse thymocytes
TL;DR: It is demonstrated that immature thymocytes lacking p53 die normally when exposed to compounds that may mimic T-cell receptor engagement and to glucocorticoids but are resistant to the lethal effects of ionizing radiation.