Journal ArticleDOI
Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results
TLDR
The reconstructed tumor from the breast cancer patient was found to have a higher oxy-deoxy hemoglobin concentration and also a higher oxygen saturation level than the background, indicating a ductal carcinoma that corresponds well to histology findings.Abstract:
Three-dimensional (3D), multiwavelength near-infrared tomography has the potential to provide new physiological information about biological tissue function and pathological transformation. Fast and reliable measurements of multiwavelength data from multiple planes over a region of interest, together with adequate model-based nonlinear image reconstruction, form the major components of successful estimation of internal optical properties of the region. These images can then be used to examine the concentration of chromophores such as hemoglobin, deoxyhemoglobin, water, and lipids that in turn can serve to identify and characterize abnormalities located deep within the domain. We introduce and discuss a 3D modeling method and image reconstruction algorithm that is currently in place. Reconstructed images of optical properties are presented from simulated data, measured phantoms, and clinical data acquired from a breast cancer patient. It is shown that, with a relatively fast 3D inversion algorithm, useful images of optical absorption and scatter can be calculated with good separation and localization in all cases. It is also shown that, by use of the calculated optical absorption over a range of wavelengths, the oxygen saturation distribution of a tissue under investigation can be deduced from oxygenated and deoxygenated hemoglobin maps. With this method the reconstructed tumor from the breast cancer patient was found to have a higher oxy-deoxy hemoglobin concentration and also a higher oxygen saturation level than the background, indicating a ductal carcinoma that corresponds well to histology findings.read more
Citations
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Developing High-Density Diffuse Optical Tomography for Neuroimaging
TL;DR: In this paper, the authors developed high-density dense optical tomography for neuroimaging using high density Diffuse Optical Tomography (DOTOMography) for brain imaging.
DissertationDOI
Mechanical and optical methods for breast cancer imaging
TL;DR: A 3D inverse-problem algorithm is developed to reconstruct the material parameters for nonlinear elastic constitutive relation of breast phantoms with tumors under external compression at breast boundaries and a nonlinear adjoint gradient method is introduced to improve the numerical efficiency and enhance the stability of elastogrpahy reconstruction.
Journal ArticleDOI
A new planar left-handed metamaterial composed of metal-dielectric-metal structure.
Ming Kang,Nian-Hai Shen,Jing Chen,Jian Chen,Ya-Xian Fan,Jianping Ding,Hui-Tian Wang,Peiheng Wu +7 more
TL;DR: An improved planar structure of left-handed (LH) metamaterial is presented, and the effective refractive index estimated by the wedge method is in excellent agreement with that retrieved by the inversion method from the transmission and reflection spectra.
Proceedings ArticleDOI
Internal refractive index changes affect light transport in tissue
TL;DR: In this paper, the influence of refractive index mismatch at boundaries within a domain was investigated. And the effect of index of refraction, as an optical property, on light transport through optically turbid media was explored.
Journal ArticleDOI
Mathematical and numerical challenges in optical screening of female breast
TL;DR: This work addresses two original points about the crucial issue of the solution of the severely ill-conditioned DOT inverse problem and proposes a computational approach based on Green's functions which do not require the exact knowledge of the tissue geometry.
References
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Journal ArticleDOI
Optical tomography in medical imaging
TL;DR: A review of methods for the forward and inverse problems in optical tomography can be found in this paper, where the authors focus on the highly scattering case found in applications in medical imaging, and to the problem of absorption and scattering reconstruction.
Journal ArticleDOI
Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation.
TL;DR: The cytochrome aa3 spectrum in vivo from the brains of rats after replacing the blood with a fluorocarbon substitute is obtained and an algorithm for calculating the changes in oxygenated and deoxygenated haemoglobin and oxygenated cy tochrome a a3 in tissue from changes in near IR absorption is constructed.
Journal ArticleDOI
Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
TL;DR: It is found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations and the use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.
Journal ArticleDOI
Imaging the body with diffuse optical tomography
David A. Boas,Dana H. Brooks,Eric L. Miller,Charles A. DiMarzio,Misha E. Kilmer,R.J. Gaudette,Quan Zhang +6 more
TL;DR: The basic idea of DOT is introduced, the history of optical methods in medicine is reviewed, and a review of the tissue's optical properties, modes of operation for DOT, and the challenges which the development of DOT must overcome are detailed.
Journal ArticleDOI
A finite element approach for modeling photon transport in tissue.
TL;DR: A finite element method for deriving photon density inside an object, and photon flux at its boundary, assuming that the photon transport model is the diffusion approximation to the radiative transfer equation, is introduced herein.