Showing papers in "Neoplasia in 2002"

TL;DR: This review attempts to describe what is currently accepted about the pathophysiology of the hypercoagulable state of cancer and discusses whether or not to screen patients with idiopathic deep venous thrombosis for an underlying malignancy, and whether this would be beneficial to patients.

TL;DR: This novel optical technology can be a significant add-on in MR examinations and can be used to characterize functional parameters of cancers with diagnostic and treatment prognosis potential and can play a major role in functional activation studies of brain and muscle as well.

TL;DR: Results suggest BID cleavage as a possible limiting factor in the involvement of mitochondria in TRAIL-induced cell death, which may define if a cell is mitochondria-dependent or -independent in response to TRAIL death receptor-induced apoptosis.

TL;DR: The data suggest that αvβ3, in part, facilitates prostate cancer metastasis to bone by mediating prostate cancer cell adhesion to and migration on osteopontin and vitronectin, which are common proteins in the bone microenvironment.

TL;DR: The data suggest that alpha(v)beta(3), in part, facilitates prostate cancer metastasis to bone by mediating prostate cancer cell adhesion to and migration on osteopontin and vitronectin, which are common proteins in the bone microenvironment.

TL;DR: The contention that deregulated overexpression of CEA and CEACAM6 could provide a tumorigenic contribution to colon carcinogenesis is supported.

TL;DR: Using a modified version of the mRNA differential display technique, five human bladder cancer cell lines from low grade to metastatic were analyzed and a gene that was not expressed in the metastatic cell line TccSuP was isolated and named Missing in Metastasis (MIM).

TL;DR: The amplification of subtelomeric DNA on the marker chromosome provides conclusive evidence that B/F/B cycles initiated by spontaneous telomere loss are a mechanism for gene amplification in human cancer cells.

TL;DR: The cross-validation test indicates the possibility of making prediction of radiosensitivity for discriminating radiation-sensitive from radiation resistant biopsy samples by predicting score (PS) values calculated from expression values of 62 genes in 19 samples, because the prediction successfully and unequivocally discriminated the radiosensitive phenotype from the radioresistant phenotype in the authors' test panel of 19 cervical carcinomas.

TL;DR: The results indicate that DW-MRI can be used for early detection of prostate carcinoma xenograft response to docetaxel chemotherapy, and the apparent diffusion coefficient of water (ADC(w)) increases significantly by 2 days even at the lowest doses (10 mg/kg).

TL;DR: It is shown that the full-length ER alpha is not expressed during estrus in the vagina of female offspring exposed to either dose of BPA when compared to the control group, whereas ER alpha expression does not differ from the control groups during the diestrus stage.

TL;DR: The fact, that IL- 13Rα2-positive cells bind IL-13 independent of IL-4, become susceptible to IL-14 cytotoxins, and cells deprived of IL -13R α2 receptor lose these features, demonstrates that IL,13Rα 2 is the brain tumor-associated receptor for IL-12.

TL;DR: It was found that the signature karyotypes of all four cell lines were distinct and each aberrant and there was a relative stability of the consensus karyotype over many generations, implying a kind of genomic optimization under the conditions of cell culture and suggesting a link between genomic stabilization and cell propagation.

TL;DR: MRI of ETR expression can serve as a surrogate for measuring therapeutic transgene expression using a nonregulatable internalizing engineered transferrin receptor whose expression can be probed for with a superparamagnetic Tf-CLIO probe.

TL;DR: Observations suggest a potential role for Bid in tumor responses to specific chemotherapeutic drugs, and lay a foundation for future investigations of this member of the Bcl-2 family in healthy and diseased tissues.

TL;DR: The data suggest that the depletion of nonsterol mevalonate metabolites, particularly GGPP, can be potential mediators of lovastatin-induced apoptosis of HNSCC and CC cells.

TL;DR: The combination of cytotoxic radiotherapy and antiangiogenic TM could target both the existing tumor and the tumor microvasculature in a comprehensive strategy for Wilson's disease.

TL;DR: The results suggest STAT6 is required for IL-4-mediated growth inhibition and induction of apoptosis in human breast cancer cells.

TL;DR: Results demonstrate that hypoxia-inducible vectors may be useful for tumor-selective gene therapy, although the problem of delivery of the vector to the tumors, particularly to the hypoxic cells in the tumor, is not addressed.

TL;DR: The data indicate substantial heterogeneity among CK in lung adenocarcinomas resulting from posttranslational modifications, some of which correlated with patient survival and other clinical parameters, Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lungAdenocARCinomas.

TL;DR: It is demonstrated that mice treated thrice weekly with intravenous Ac-PHSCN-NH(2) peptide survived tumor-free for more than 30 weeks post-primary tumor excision, whereas their untreated counterparts succumbed to recurrence and/or metastatic disease in significantly less time.

TL;DR: Three tumor phenotypes associated with two different adhesion complexes were identified, suggesting a reorganization of cell adhesion structures in prostate cancer.

TL;DR: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of transformed cell lines, but generally spares most normal cells, so vector-mediated transduction of TRAIL may represent an effective strategy for cancer gene therapy.

TL;DR: Although overexpression of MYC is not sufficient to cause intraparenchymal tumors, it may facilitate PNET formation by sustaining the growth of undifferentiated progenitor cells in culture and in the cerebral leptomeninges in vivo.

TL;DR: VT1 treatment of MM is effective in the authors' orthotopic xenograft model, and warrants further exploration as a potential treatment for these highly anaplastic and aggressive neoplasms.

TL;DR: High-grade murine gliomas have histologic characteristics of glioblastoma multiforme with contrast enhancement after intravenous administration of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), implying disruption of the blood-brain barrier in these tumors.

TL;DR: Overexpression of URG4 in HepG2 cells promoted hepatocellular growth and survival in tissue culture and in soft agar, and accelerated tumor development in nude mice, suggestingURG4 may be a natural effector of HBxAg that contributes importantly to multistep hepatocarcinogenesis.

TL;DR: The results indicate that intracellular proteolysis can be imaged in vivo at the cellular level using cathepsin-sensitive probes and tumor-recruited cells of hematopoetic origin participate most actively in uptake and degradation of long-circulating macromolecular probes.

TL;DR: Results suggest that Sema3B might play some role in regulating cell growth as a mediator of p53 tumor-suppressor activity.

TL;DR: Progress employing novel mouse targeting strategies has begun to illuminate the roles of the NF1 and NF2 gene products in the molecular pathogenesis of NF-associated tumors.