Journal ArticleDOI
Multiwavelength three-dimensional near-infrared tomography of the breast: initial simulation, phantom, and clinical results
TLDR
The reconstructed tumor from the breast cancer patient was found to have a higher oxy-deoxy hemoglobin concentration and also a higher oxygen saturation level than the background, indicating a ductal carcinoma that corresponds well to histology findings.Abstract:
Three-dimensional (3D), multiwavelength near-infrared tomography has the potential to provide new physiological information about biological tissue function and pathological transformation. Fast and reliable measurements of multiwavelength data from multiple planes over a region of interest, together with adequate model-based nonlinear image reconstruction, form the major components of successful estimation of internal optical properties of the region. These images can then be used to examine the concentration of chromophores such as hemoglobin, deoxyhemoglobin, water, and lipids that in turn can serve to identify and characterize abnormalities located deep within the domain. We introduce and discuss a 3D modeling method and image reconstruction algorithm that is currently in place. Reconstructed images of optical properties are presented from simulated data, measured phantoms, and clinical data acquired from a breast cancer patient. It is shown that, with a relatively fast 3D inversion algorithm, useful images of optical absorption and scatter can be calculated with good separation and localization in all cases. It is also shown that, by use of the calculated optical absorption over a range of wavelengths, the oxygen saturation distribution of a tissue under investigation can be deduced from oxygenated and deoxygenated hemoglobin maps. With this method the reconstructed tumor from the breast cancer patient was found to have a higher oxy-deoxy hemoglobin concentration and also a higher oxygen saturation level than the background, indicating a ductal carcinoma that corresponds well to histology findings.read more
Citations
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Journal ArticleDOI
Mechanical property assessment of tissue-mimicking phantoms using remote palpation and optical read-out for amplitude of vibration and refractive index modulation.
TL;DR: In this article, a coherent light beam is used to interrogate the focal region within a tissue-mimicking phantom insonified by an ultrasound transducer, and it is shown that the amplitude is directed along the axis of the transducers.
Journal ArticleDOI
Multi-modulated frequency domain high density diffuse optical tomography
TL;DR: In this article , the frequency domain (FD) high density diffuse optical tomography (HD-DOT) using varying or combined modulation frequencies (mFD) has shown to theoretically improve the imaging accuracy as compared to conventional continuous wave (CW) measurements.
Proceedings ArticleDOI
Adaptive selection of minimally correlated data for optimization of source-detector configuration in diffuse optical tomography
TL;DR: It is shown that the source/detector pairs selected by EFI method were least prone to vary with sub optimal regularization value, and it was confirmed that sparse source-detector pair measurements selected byEFI method offered similar results in comparison with the dense measurement configuration for unknown parameters qualitatively as well as quantitatively.
Proceedings ArticleDOI
Non-contact fluorescence tomography using a cone-beam CT surgical guidance system
Michael J. Daly,Harley H.L. Chan,Nidal Muhanna,Margarete K. Akens,Margarete K. Akens,Brian C. Wilson,Brian C. Wilson,Jonathan C. Irish,Jonathan C. Irish,David A. Jaffray,David A. Jaffray +10 more
TL;DR: This work investigates the use of a cone-beam CT (CBCT) surgical guidance system to generate spatial priors for intraoperative DOFT in an ongoing CBCT-guided head and neck surgery patient study.
Proceedings ArticleDOI
Development of a dynamic optical tomographic breast imaging system with digital detection techniques
Molly Lara Flexman,James M. Masciotti,Michael A. Khalil,Alisha Ling,Rabah M. Al abdi,Randall L. Barbour,Andreas H. Hielscher +6 more
TL;DR: In this article, a digital near-infrared mammography system was developed specifically for the purpose of dynamic breast imaging, which simultaneously acquired four frequency encoded wavelengths of light at 765, 808, 827, and 905nm in order to facilitate the functional imaging of oxy and deoxy-hemoglobin, lipid concentration and water content.
References
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Journal ArticleDOI
Optical tomography in medical imaging
TL;DR: A review of methods for the forward and inverse problems in optical tomography can be found in this paper, where the authors focus on the highly scattering case found in applications in medical imaging, and to the problem of absorption and scattering reconstruction.
Journal ArticleDOI
Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation.
TL;DR: The cytochrome aa3 spectrum in vivo from the brains of rats after replacing the blood with a fluorocarbon substitute is obtained and an algorithm for calculating the changes in oxygenated and deoxygenated haemoglobin and oxygenated cy tochrome a a3 in tissue from changes in near IR absorption is constructed.
Journal ArticleDOI
Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
TL;DR: It is found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations and the use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.
Journal ArticleDOI
Imaging the body with diffuse optical tomography
David A. Boas,Dana H. Brooks,Eric L. Miller,Charles A. DiMarzio,Misha E. Kilmer,R.J. Gaudette,Quan Zhang +6 more
TL;DR: The basic idea of DOT is introduced, the history of optical methods in medicine is reviewed, and a review of the tissue's optical properties, modes of operation for DOT, and the challenges which the development of DOT must overcome are detailed.
Journal ArticleDOI
A finite element approach for modeling photon transport in tissue.
TL;DR: A finite element method for deriving photon density inside an object, and photon flux at its boundary, assuming that the photon transport model is the diffusion approximation to the radiative transfer equation, is introduced herein.