Journal ArticleDOI
Muscle performance after the menopause.
Joonas Sirola,Toni Rikkonen +1 more
TLDR
Improvement or maintenance of muscle strength alone may not be considered as a primary indication for long-term hormone replacement therapy in view of current knowledge of its risks and benefits.Abstract:
The timing of the menopause transition has remained fairly constant throughout history. It represents a milestone in female health and, after passing through it, women experience increased musculoskeletal and cardiovascular morbidity. Muscle performance is an important determinant of functional capacity and quality of life among the elderly and is also involved in the maintenance of balance. Therefore, good muscle strength can prevent fragility fractures and lessen the burden of osteoporosis. Muscle strength begins to decline during the perimenopausal years and this phenomenon seems to be partly estrogen dependent. Randomized controlled trials have indicated that hormone replacement therapy may prevent a decline in muscle performance, although the exact mechanism of estrogen-dependent sarcopenia remains to be clarified. Exercises have been shown to improve postmenopausal muscle performance and hormone replacement therapy may also potentiate these beneficial effects. Improvement or maintenance of muscle strength alone, however, may not be considered as a primary indication for long-term hormone replacement therapy in view of current knowledge of its risks and benefits. Work history and educational background may be associated with postmenopausal muscle performance, which itself has unique associations with skeletal and cardiovascular diseases.read more
Citations
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Journal ArticleDOI
Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures.
TL;DR: The mechanisms underlying MetS-related sarcopenia are reviewed and the possible therapeutic measures proposed and lifestyle changes including diet and power exercise seem to be the best options.
Journal ArticleDOI
Isokinetic and isometric muscle strength in a healthy population with special reference to age and gender
Bente Danneskiold-Samsøe,Else Marie Bartels,Else Marie Bartels,P. M. Bülow,Hans Lund,Anders Stockmarr,Christian C. Holm,I. Wätjen,M Appleyard,Henning Bliddal +9 more
TL;DR: The aim of the present study was to measure a set of normal values for isometric and isokinetic muscle strength for all the major joint movements of the body and create a basis for comparison of the muscle strength of an individual with the expected value in a normal population.
Journal ArticleDOI
Hormone Therapy and Skeletal Muscle Strength: A Meta-Analysis
TL;DR: Overall, estrogen-based treatments were found to beneficially affect strength in postmenopausal women.
Journal ArticleDOI
Skeletal muscle and bone: effect of sex steroids and aging
TL;DR: Hormonal supplementation of older adults to restore estrogen and testosterone levels to those of young men and women is not without penalty.
Journal ArticleDOI
Monocyte-macrophage system as a target for estrogen and selective estrogen receptor modulators.
TL;DR: Regulation of the monocyte–macrophage system by estrogen and cross‐talk between the ER and cytokine‐mediated pathways provides multiple novel targets for development of selective ER modulator (SERM) molecules for prevention and treatment of postmenopausal degenerative and neoplastic diseases.
References
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Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Bone “mass” and the “mechanostat”: A proposal
TL;DR: The observed fit of bone mass to a healthy animal's typical mechanical usage indicates some mechanism or mechanisms monitor that usage and control the three longitudinal growth, bone modeling, and BMU‐based remodeling activities that directly determine bone mass.
Journal ArticleDOI
Muscle strength and speed of movement in relation to age and muscle morphology
TL;DR: Multiple regression analyses indicated that mechanisms other than the type II fiber atrophy might be responsible for the decline in strength performance during aging.
Journal ArticleDOI
Estrogen production and action
Linda R. Nelson,Serdar E. Bulun +1 more
TL;DR: There can be complex mechanisms that regulate the extraglandular production of estrogen in a tissue-specific and state-specific fashion, and local estrogen biosynthesis by aromatase activity in the brain may be important in the regulation of various cognitive and hypothalamic functions.
Journal ArticleDOI
Falls in the elderly related to postural imbalance.
TL;DR: In both sexes sway was significantly increases in people who fell because of loss of balance and in women whose falls were due to giddiness, drop attacks, turning the head, and rising from bed or a chair, suggesting that there is a physiological decline in postural control with advancing age and also a decline due to disease of the central nervous system.