Mycoplasma pneumoniae from the Respiratory Tract and Beyond
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TLDR
This review focuses on the many new developments that have occurred over the past several years that enhance the understanding of this microbe, which is among the smallest bacterial pathogens but one of great clinical importance.Abstract:
Mycoplasma pneumoniae is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening Over the past several years there has been much new information published concerning infections caused by this organism New molecular-based tests for M pneumoniae detection are now commercially available in the United States, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections More strains have had their entire genome sequences published, providing additional insights into pathogenic mechanisms Clinically significant acquired macrolide resistance has emerged worldwide and is now complicating treatment In vitro susceptibility testing methods have been standardized, and several new drugs that may be effective against this organism are undergoing development This review focuses on the many new developments that have occurred over the past several years that enhance our understanding of this microbe, which is among the smallest bacterial pathogens but one of great clinical importanceread more
Citations
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Journal ArticleDOI
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children
Hyunju Lee,Hyunju Lee,Ki Wook Yun,Ki Wook Yun,Hoan Jong Lee,Hoan Jong Lee,Eun Hwa Choi,Eun Hwa Choi +7 more
TL;DR: Clinical benefit of tetracyclines and fluoroquinolones has been shown in terms of shortening duration of symptoms and rapid defervescence in some reports, however, due to safety concerns regarding these two alternative antibiotics, clinicians should weigh the risks and benefits when choosing treatment options.
Journal ArticleDOI
Mycoplasma pneumoniae : A Potentially Severe Infection
TL;DR: A concise and up-to-date review of the current knowledge of Mycoplasma pneumoniae pneumonia is presented.
Antibiotics for community-acquired lower respiratory tract infections secondary to Mycoplasma pneumoniae in children (Review)
TL;DR: There is insufficient evidence to draw any specific conclusions about the efficacy of antibiotics for this condition in children (although one trial suggests macrolides may be efficacious in some children with LRTI secondary to Mycoplasma), so the use of antibiotics has to be balanced with possible adverse events.
Journal ArticleDOI
Extra-pulmonary diseases related to Mycoplasma pneumoniae in children: recent insights into the pathogenesis.
TL;DR: The awareness of the occurrence of MpEPDs, showing very variable clinical expressions, could promote a correct diagnosis and an appropriate treatment and recent advances from clinical studies and murine models might promote and direct future research.
Journal ArticleDOI
Frequency and Clinical Presentation of Mucocutaneous Disease Due to Mycoplasma pneumoniae Infection in Children With Community-Acquired Pneumonia.
Patrick M. Meyer Sauteur,Martin Theiler,Martin Theiler,Michael Buettcher,Michelle Seiler,Lisa Weibel,Lisa Weibel,Christoph Berger +7 more
TL;DR: M pneumoniae-induced mucocutaneous disease in children with community-acquired pneumonia was associated with increased systemic inflammation, morbidity, and a higher risk of long-term sequelae.
References
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Loop-mediated isothermal amplification of DNA
Tsugunori Notomi,Hiroto Okayama,Harumi Otawara-shi Masubuchi,Toshihiro Yonekawa,Keiko Watanabe,Nobuyuki Amino,Tetsu Hase +6 more
TL;DR: A novel method that amplifies DNA with high specificity, efficiency and rapidity under isothermal conditions that employs a DNA polymerase and a set of four specially designed primers that recognize a total of six distinct sequences on the target DNA.
Journal ArticleDOI
From the Centers for Disease Control and Prevention
TL;DR: This report summarizes the clinical features of these cases and the epidemiologic investigations by the Texas Department of Health and the New Jersey State Department of health and Senior Services, which indicated that a bat-associated variant of the rabies virus was responsible for infection in both cases.
Journal ArticleDOI
Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults
Lionel A. Mandell,Richard G. Wunderink,Antonio Anzueto,John G. Bartlett,G. Douglas Campbell,Nathan C. Dean,Nathan C. Dean,Scott F. Dowell,Daniel M. Musher,Daniel M. Musher,Michael S. Niederman,Michael S. Niederman,Antoni Torres,Cynthia G. Whitney,Michael E. DeBakey Veterans +14 more
TL;DR: This work presents a meta-analyses of the immune system’s response to chronic obstructive pulmonary disease and shows clear patterns of decline in the immune systems of elderly patients with compromised immune systems.
Journal ArticleDOI
Community-acquired pneumonia requiring hospitalization among U.S. adults
Seema Jain,Derek J. Williams,Sandra R. Arnold,Krow Ampofo,Anna M. Bramley,Carrie Reed,Chris Stockmann,Evan J. Anderson,Carlos G. Grijalva,Wesley H. Self,Yuwei Zhu,Anami Patel,Weston Hymas,James D. Chappell,Robert A. Kaufman,J. Herman Kan,David Dansie,Noel Lenny,David R. Hillyard,Lia M. Haynes,Min Z. Levine,Stephen Lindstrom,Jonas M. Winchell,Jacqueline M. Katz,Dean D. Erdman,Eileen Schneider,Lauri A. Hicks,Richard G. Wunderink,Kathryn M. Edwards,Andrew T. Pavia,Jonathan A. McCullers,Lyn Finelli +31 more
TL;DR: The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults and despite current diagnostic tests, no pathogen was detected in the majority of patients.
Journal ArticleDOI
The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America
John S. Bradley,Carrie L. Byington,Samir S. Shah,Brian Alverson,Edward R. Carter,Christopher J. Harrison,Sheldon L. Kaplan,Sharon E. Mace,George H. McCracken,Matthew R. Moore,Shawn D. St. Peter,Jana A. Stockwell,Jack Swanson +12 more
TL;DR: Eidenced-based guidelines for management of infants and children with community-acquired pneumonia (CAP) were prepared by an expert panel comprising clinicians and investigators representing community pediatrics, public health, and the pediatric specialties of critical care, emergency medicine, hospital medicine, infectious diseases, pulmonology, and surgery.
Related Papers (5)
Community-acquired pneumonia requiring hospitalization among U.S. adults
Seema Jain,Derek J. Williams,Sandra R. Arnold,Krow Ampofo,Anna M. Bramley,Carrie Reed,Chris Stockmann,Evan J. Anderson,Carlos G. Grijalva,Wesley H. Self,Yuwei Zhu,Anami Patel,Weston Hymas,James D. Chappell,Robert A. Kaufman,J. Herman Kan,David Dansie,Noel Lenny,David R. Hillyard,Lia M. Haynes,Min Z. Levine,Stephen Lindstrom,Jonas M. Winchell,Jacqueline M. Katz,Dean D. Erdman,Eileen Schneider,Lauri A. Hicks,Richard G. Wunderink,Kathryn M. Edwards,Andrew T. Pavia,Jonathan A. McCullers,Lyn Finelli +31 more
Carriage of Mycoplasma pneumoniae in the Upper Respiratory Tract of Symptomatic and Asymptomatic Children: An Observational Study
Emiel B. M. Spuesens,Pieter L. A. Fraaij,Eline G. Visser,Theo Hoogenboezem,Wim C. J. Hop,Leon N. A. van Adrichem,Frank Weber,Henriëtte A. Moll,Berth Broekman,Marjolein Y. Berger,Tineke van Rijsoort-Vos,Alex van Belkum,Alex van Belkum,Martin Schutten,Suzan D. Pas,Albert D. M. E. Osterhaus,Nico G. Hartwig,Cornelis Vink,Annemarie M. C. van Rossum +18 more