Journal ArticleDOI
Nanoparticles targeting tumor-associated macrophages: A novel anti-tumor therapy
TLDR
In this paper, the authors provide a brief overview of the role of TAMs in the tumor microenvironment and their functions and highlight strategies for TAM targeting, and the applications of nanoparticles in targeting TAMs to improve cancer therapeutic efficiency are summarized.Abstract:
The immunosuppressive tumor microenvironment (TME) is crucial in the occurrence of tumorigenesis, metastasis, and drug resistance. Among all stromal cells, tumor-associated macrophages (TAMs) are recognized as vital components causing the TME to be favorable for cancer cells and are also main targets in cancer immunotherapy. To date, nanoparticle (NP)-based drug delivery systems, as new technology platforms, have exhibited considerable advantages, such as targeted drug delivery at tumor sites, enhanced drug transport efficiency, and controllable drug release profiles, which provide new approaches for cancer therapy. Regarding TAM-targeting nanoparticles, various therapeutic strategies have been developed by varying their design, namely, by blocking TAM recruitment, promoting TAM transformation, and directly diminishing existing TAMs. In the current review, we provide a brief overview of the role of TAMs in the tumor microenvironment and their functions and highlight strategies for TAM targeting. Moreover, the applications of nanoparticles in targeting TAMs to improve cancer therapeutic efficiency are summarized.read more
Citations
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Journal ArticleDOI
Flavonoid-Based Nanomedicines to Target Tumor Microenvironment
TL;DR: In this article , a comprehensive analysis of flavonoid-based nanomedicine was provided with special emphasis on tumor microenvironment components as therapeutic targets, including stromal cells and extracellular matrix.
Journal ArticleDOI
Stimuli-responsive nanoassemblies for targeted delivery against tumor and its microenvironment.
TL;DR: In this paper , stimuli-responsive nano-assemblies capable of combating the tumor microenvironment (TME) are discussed, and strategies to overcome these barriers for successful drug delivery to the targeted site are reviewed and summarized.
Journal ArticleDOI
Intraperitoneal administration of PLGA nanoparticles could deliver the cargo to tumor-associated macrophages with less spreading peritoneal macrophages in the treatment of peritoneal carcinomatosis
Adem Sahin,Sule Ozturk +1 more
TL;DR: In this article , the authors used PLGA nanoparticles to deliver drugs to tumor-associated macrophages (TAMs) in peritoneal metastasis in colorectal adenocarcinoma.
Journal ArticleDOI
Mannose-Coated Reconstituted Lipoprotein Nanoparticles for the Targeting of Tumor-Associated Macrophages: Optimization, Characterization, and In Vitro Evaluation of Effectiveness
Akpedje Serena Dossou,William Burnett,Nirupama Sabnis,Jeffery L. Coffer,Rance E. Berg,Rafal Fudala,Andras G. Lacko +6 more
TL;DR: In this article , a mannose-coated high-density lipoprotein nanoparticles (rHDL-DPM-DMXAA NPs) were combined with recombinant apolipoprotein A-I, DMXAA, and different amounts of DSPE-PEG-mannose (DPM) for the targeting of TAMs.
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