Journal ArticleDOI
Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase III multicentre randomised controlled trial
Su Mei Cao,Qi Yang,Ling Guo,Hai Qiang Mai,Hao Yuan Mo,Ka Jia Cao,Chao Nan Qian,Chong Zhao,Yan Qun Xiang,Xiu Ping Zhang,Zhi Xiong Lin,Wei Xiong Li,Qing Liu,Fang Qiu,Rui Sun,Qiu Yan Chen,Pei Yu Huang,Dong Hua Luo,Yi Jun Hua,Yi Shan Wu,Xing Lv,Lin Wang,Wei Xiong Xia,Lin Quan Tang,Yan Fang Ye,Ming Yuan Chen,Xiang Guo,Ming Huang Hong +27 more
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TLDR
NACT improved tumour control compared with CCRT alone in locoregionally advanced NPC, particularly at distant sites, however, there was no early gain in OS.About:
This article is published in European Journal of Cancer.The article was published on 2017-04-01. It has received 201 citations till now. The article focuses on the topics: Chemoradiotherapy & Nasopharyngeal neoplasm.read more
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Early Stage and Locally Advanced Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Going?
Juan José Juárez-Vignon Whaley,Michelle Afkhami,Sagus Sampath,Arya Amini,Diana Bell,Victoria M. Villaflor +5 more
TL;DR: Wang et al. as mentioned in this paper proposed a molecularly guided treatment targeting patients with Nasopharyngeal carcinoma whether driven by Epstein-Barr virus (EBV) or tobacco and alcohol.
References
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New Guidelines to Evaluate the Response to Treatment in Solid Tumors
Patrick Therasse,Susan G. Arbuck,Elizabeth Eisenhauer,Jantien Wanders,Richard Kaplan,Larry Rubinstein,Jaap Verweij,Martine Van Glabbeke,Allan T. van Oosterom,Michaele C. Christian,S. Gwyther +10 more
TL;DR: A model by which a combined assessment of all existing lesions, characterized by target lesions and nontarget lesions, is used to extrapolate an overall response to treatment is proposed, which is largely validated by the Response Evaluation Criteria in Solid Tumors Group and integrated into the present guidelines.
Journal ArticleDOI
Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC)
TL;DR: The Late Morbidity Scoring Criteria were developed as a joint effort between physicians with renewed interests in fast neutron therapy and Radiation Therapy Oncology Group (RTOG) staff to represent cumulative probabilities of late effects with methods similar to those for estimating local control and survival.
Journal ArticleDOI
Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099.
Muhyi Al-Sarraf,Michael LeBlanc,P.G. Giri,Karen K. Fu,Jay S. Cooper,T. Vuong,Arlene A. Forastiere,George L. Adams,Wael Sakr,David E. Schuller,John F. Ensley +10 more
TL;DR: It is concluded that chemoradiotherapy is superior to radiotherapy alone for patients with advanced nasopharyngeal cancers with respect to PFS and overall survival.
Journal ArticleDOI
Phase III Study of Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Advanced Nasopharyngeal Carcinoma: Positive Effect on Overall and Progression-Free Survival
TL;DR: It is concluded that CCRT is superior to RT alone for patients with advanced NPC in endemic areas.
Journal ArticleDOI
Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety
Joseph Wee,Eng Huat Tan,Bee Choo Tai,Hwee Bee Wong,Swan Swan Leong,Terence Tan,Eu Tiong Chua,Edward Yang,Khai Mun Lee,Kam Weng Fong,Hoon Seng Khoo Tan,Lee Ks,Susan Loong,Vijay K Sethi,Eu Jin Chua,David Machin +15 more
TL;DR: It is confirmed that chemotherapy improves the distant metastasis control rate in NPC and its applicability to endemic NPC is demonstrated.
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