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Nerve Growth Factor and Insulin
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SCIENCE is published weekly, except the last week in December, but with an extra issue on the third Tuesday in November, by the American Association for the Advancement Science, 1515 Massachusetts Ave., NW, Washington, D.C. 20005.Abstract:
SCIENCE is published weekly, except the last week in December, but with an extra issue on the third Tuesday in November, by the American Association for the Advancement Science, 1515 Massachusetts Ave., NW, Washington, D.C. 20005. Now combined with The Scientific Monthly. Second-class postage paid at Washington, D.C. Copyright t 1972 the American Association for the Advancement of Science. Annual subscription $20; foreign postage: Americas $3; overseas $5; 'air freight to Europe, North Africa, Near East $ single copies $1 (back issues, $2) except Guide to Scientific Instruments which is $4. School year subscription: 9 months, $15; 10 mnh,$67,Poide 4 weeks notice change of address, giving new and old address and zip codes. Send a recent address label. SCIENCE is indexed in the Reader's Guide to Periodical LIteature. EDITORIALread more
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Journal ArticleDOI
The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.
E Rinderknecht,R E Humbel +1 more
TL;DR: The number of differences in amino acid positions between IGF-I and insulins suggests that duplication of the gene of the common ancestor of proinsulin and IGF occurred before the time of appearance of the vertebrates.
Journal ArticleDOI
Expression and structure of the human NGF receptor
Daniel Johnson,Anthony Lanahan,C.Randy Buck,Amita Sehgal,Claudia Morgan,Eric H. Mercer,Mark Bothwell,Moses V. Chao +7 more
TL;DR: Transfection of a full-length cDNA in mouse fibroblasts results in stable expression of NGF receptors that are recognized by monoclonal antibodies to the human NGF receptor and that bind [125I]NGF.
Journal ArticleDOI
Similar Amino Acid Sequences: Chance or Common Ancestry?
TL;DR: The systemic comparison of every newly determined amino acid sequence with all other known sequences may allow a complete reconstruction of the evolutionary events leading to contemporary proteins, but sometimes the surviving similarities are so vague that even computer-based sequence comparisons procedures are unable to validate relationships.
Journal ArticleDOI
Primary structure of human insulin-like growth factor II.
References
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Journal ArticleDOI
The nerve growth factor: purification as a 30,000-molecular-weight protein
TL;DR: The nerve growth factor protein was purified over 100-fold from adult mouse salivary glands by a gel filtration on Sephadex G-100 at pH 7.5 and the over-all recovery was about 45 per cent.
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The disulphide bonds of insulin
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Ultrastructure and function of growth cones and axons of cultured nerve cells
TL;DR: Dorsal root ganglion nerve cells undergoing axon elongation in vitro have been analyzed ultrastructurally and it is suggested that this filamentous network could provide the structural basis for the initiation of lateral microspikes and perhaps of collateral axons, besides playing a role in axonal transport.
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Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein.
TL;DR: This study finds a remarkable decrease in size of the sympathetic ganglia of the injected mice prompted an extensive investigation of the effects of the antiserum on the sympathetic Ganglia of mice and other mammals.