Journal ArticleDOI
Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their projections in the guinea-pig small intestine
John B. Furness,Marcello Costa +1 more
TLDR
It is deduced that varicose fibres immunoreactive for 5-hydroxytryptamine, which occur around the enteric ganglion cells of both plexuses arise from nerve cell bodies in myenteric ganglia than send their axons in an anal direction.About:
This article is published in Neuroscience.The article was published on 1982-02-01. It has received 256 citations till now. The article focuses on the topics: Myenteric plexus & Enteric nervous system.read more
Citations
More filters
Journal ArticleDOI
The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
Michael D. Gershon,Jan Tack +1 more
TL;DR: Serotonin is an important gastrointestinal signaling molecule as mentioned in this paper, which is used by enterochromaffin (EC) cells to activate intrinsic and extrinsic primary afferent neurons to initiate peristaltic and secretory reflexes and transmit information to the central nervous system.
Journal ArticleDOI
The enteric nervous system and neurogastroenterology
TL;DR: This Review provides a broad overview of the field of neurogastroenterology, with a focus on the roles of the ENS in the control of the musculature of the gastrointestinal tract and transmucosal fluid movement.
Journal ArticleDOI
Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets
Gary M. Mawe,Jill M. Hoffman +1 more
TL;DR: Emerging evidence suggests that exploiting epithelial targets with nonabsorbable serotonergic agents could provide safe and effective therapies, and this work provides an overview of theseserotonergic actions and treatment strategies.
Journal ArticleDOI
5-Hydroxytryptamine (serotonin) in the gastrointestinal tract.
TL;DR: New studies show that enteric 5-HT is a polyfunctional signalling molecule, acting both in developing and mature animals as a neurotransmitter paracrine factor, endocrine hormone and growth factor.
Journal ArticleDOI
Neurochemical classification of myenteric neurons in the guinea-pig ileum
Marcello Costa,Simon J. H. Brookes,P.A. Steele,Ian L. Gibbins,Elizabeth Burcher,C. J. Kandiah +5 more
TL;DR: A strategy has been developed to identify and quantify the different neurochemical populations of myenteric neurons in the guinea-pig ileum using double-labelling fluorescence immunohistochemistry of whole-mount preparations, and a classification scheme, consistent with previous studies, is proposed.
References
More filters
Journal ArticleDOI
Two kinds of tryptamine receptor
J. H. Gaddum,Z. P. Picarelli +1 more
TL;DR: There are two kinds of tryptamine receptor in the guinea-pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which have no additional effect after dibenzyline.
Journal ArticleDOI
Immunohistochemical localization of polypeptides in peripheral autonomic nerves using whole mount preparations.
Marcello Costa,Marcello Costa,R. Buffa,R. Buffa,John B. Furness,John B. Furness,E. Solcia,E. Solcia +7 more
TL;DR: This procedure ensures adequate penetration of the antibody molecules without the need to freeze and thaw the tissue or to use detergents, preserves antigenicity and lowers non-specific background staining.
Journal ArticleDOI
The peristaltic reflex: An analysis of the nerve pathways and their pharmacology
Marcello Costa,John B. Furness +1 more
TL;DR: It is postulated that three factors may contribute to propulsion in the guinea-pig distal colon: ascending excitatory reflexes which evoke contractions above a bolus; descending inhibitory Reflexes which cause relaxations below; and contractions which, once set up in the circular muscle, travel in an anal direction.
Journal ArticleDOI
Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their visualization and reactions to drug treatment.
TL;DR: There are two classes of aromatic amine neuron in the guinea-pig small intestine, the enteric 5-HT neurons and enteric, non-5-HT, amine handling neurons, compared with the distribution of enteric amine-handling neurons that take up and decarboxylate L-dopa.
Journal ArticleDOI
Serotonergic activation of tonic-type enteric neurons in guinea pig small bowel
J. D. Wood,C. J. Mayer +1 more
TL;DR: The evidence suggests that 5-HT is the neurotransmitter substance that produces the slow EPSP in myenteric neurons, which is associated with an increase in input resistance in the postsynaptic neuron.