Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression.
TLDR
By promoting antioxidant-related Nrf2 signaling pathways in the ventral midbrain, matrine can inhibit the oxidative damage of dopamine neurons in PD.Abstract:
The incidence rate of Parkinson's disease (PD) is ≤2% in Chinese individuals >65 years old, accounting for 40% of the global total of PD patients. The pathogenesis of PD is not yet clear, and oxidative stress-induced mitochondrial dysfunction is considered to be the main reason for the onset of PD. Studies have shown that matrine exhibits good antioxidant activity. Thus, the present study aimed to observe the protective effect and mechanism of matrine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neuron damage. A total of 25 C57BL male mice were randomly divided into 5 groups, consisting of the control group (group A), the MPTP group (group B) and three matrine (4, 8 and 16 mg/kg) plus MPTP treatment groups (groups C, D and E, respectively). Results from a pole-climbing test and locomotor activity experiments were recorded. The mice were sacrificed 4 days later and brain dissection was performed. The levels of superoxide dismutase (SOD) and glutathione (GSH) were assessed. The expression level of tyrosine hydroxylase (TH) in the ventral midbrain was studied by immunofluorescence analysis. The expression level of nuclear factor erythroid 2-related factor 2 (Nrf2) in the ventral midbrain was studied by western blot analysis. The experiments were repeated three times. Compared with control mice, the PD mice exhibited the typical behaviors associated with PD; matrine can alleviate this phenomenon, and with increasing matrine concentration, the symptoms were reduced significantly. Compared with the control mice, the PD mice had lower SOD and GSH activity, and matrine partially reversed the change in SOD and GSH activity. Immunofluorescence analysis showed that the level of TH in the ventral midbrain decreased significantly in the PD mice, and that the mice administered matrine showed higher expression of TH and levels of TH-positive cells. Western blotting results showed that the expression of Nrf2 in the ventral midbrain decreased significantly in the PD mice, and that matrine was able to reverse this phenomenon. In conclusion, by promoting antioxidant-related Nrf2 signaling pathways in the ventral midbrain, matrine can inhibit the oxidative damage of dopamine neurons in PD.read more
Citations
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NRF2 as a Therapeutic Target in Neurodegenerative Diseases.
Mikah S. Brandes,Nora E. Gray +1 more
TL;DR: Evidence for a beneficial role of NRF2 in neurodegenerative conditions and the potential of specificNRF2 activators as therapeutic agents are reviewed.
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Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury
Adnan Khan,Bushra Shal,Muhammad Naveed,Fawad Ali Shah,Ayesha Atiq,Naseem Ullah Khan,Yeong Shik Kim,Salman Khan +7 more
TL;DR: The present data revealed that hyperammonemia produced due to liver injury induced oxidative stress, neuroinflammation, reduced neurogenesis and apoptosis in the hippocampus, thus, resulting in anxiety and depression.
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Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress.
TL;DR: MAT ameliorated aging-related disorder caused by D-gal through the inhibition of both cellular senescence and oxidative stress and provided further evidence for drug development of MAT for prevention or treatment of the aging-associated disorder.
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Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway
Min Gi Jo,Muhammad Ikram,Myeung Hoon Jo,Lang Yoo,Kwang Chul Chung,Seung Yeol Nah,Hongik Hwang,Hyewhon Rhim,Myeong Ok Kim +8 more
TL;DR: The in vivo and in vitro findings suggest that the neuroprotective effects of gintonin were associated with the regulation of the Nrf2/HO-1 pathway, which regulated the expression of proinflammatory cytokines and nitric oxide synthase and apoptotic markers in the substantia nigra and striatum of the mice.
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A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine.
Longtai You,Chunjing Yang,Yuanyuan Du,Wenping Wang,Mingyi Sun,Jing Liu,Baorui Ma,Linnuo Pang,Yawen Zeng,Zhiqin Zhang,Xiaoxv Dong,Xingbin Yin,Jian Ni +12 more
TL;DR: This review summarizes the latest advances in research on the pharmacology, toxicology, and pharmacokinetics of MT, with a focus on its biological properties and mechanism of action.
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