Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine
TLDR
In this article , the neutralization of BNT162b2-vaccinated sera (collected at 1 month after dose 3) against the three Omicron sublineages was reported.Abstract:
Abstract The newly emerged Omicron SARS-CoV-2 has 3 distinct sublineages: BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge and is being replaced by BA.2, whereas BA.3 is at a low prevalence at this time. Here we report the neutralization of BNT162b2-vaccinated sera (collected at 1 month after dose 3) against the three Omicron sublineages. To facilitate the neutralization testing, we engineered the complete BA.1, BA.2, or BA.3 spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All BNT162b2-vaccinated sera neutralized USA-WA1/2020, BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s with titers of >20; the neutralization geometric mean titers (GMTs) against the four viruses were 1211, 336, 300, and 190, respectively. Thus, the BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s were 3.6-, 4.0-, and 6.4-fold less efficiently neutralized than the USA-WA1/2020, respectively. Our data have implications in vaccine strategy and understanding the biology of Omicron sublineages. read more
Citations
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Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
TL;DR: In this article , the neutralization of BA.1-infected sera against BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16.
Journal ArticleDOI
Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
TL;DR: In this article , the neutralization of BA.1-infected sera against BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2s with geometric mean titers (GMTs) of 445, 107, 102, and 16.
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Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection
TL;DR: In this article , the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1.1-infected individuals was reported.
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A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants
Geraldine Nouailles,Julia Adler,Peter Pennitz,Stefan Peidli,Gustavo Teixeira Alves,Morris Baumgart,Judy Bushe,A. Voss,Alina Langenhagen,Fabian Pott,Julia Kazmierski,Cengiz Goekeri,Szandor Simmons,Na Xing,Christine Langner,Ricardo Martin Vidal,Azza Abdelrahman Abdelgawad,Susanne Herwig,Günter Cichon,Daniela Niemeyer,Christian Drosten,Christine Goffinet,Markus Landthaler,Nils Blüthgen,Haibo Wu,Martin Witzenrath,Achim D. Gruber,Samantha D. Praktiknjo,Nikolaus Osterrieder,Emanuel Wyler,Dusan Kunec,Jakob Trimpert +31 more
TL;DR: The results demonstrate that use of live-attenuated vaccines may offer advantages over available CO VID-19 vaccines, specifically when applied as booster, and may provide a solution for containment of the COVID-19 pandemic.
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Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
TL;DR: In this article , the neutralization of BA.1-infected sera against BA.2, BA.3, and USA/WA1-2020 SARS-CoV-2 was evaluated.
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Journal ArticleDOI
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Xuping Xie,Antonio E. Muruato,Kumari G. Lokugamage,Krishna Narayanan,Xianwen Zhang,Jing Zou,Jianying Liu,Craig Schindewolf,Nathen E. Bopp,Patricia V. Aguilar,Kenneth S. Plante,Scott C. Weaver,Shinji Makino,James W. LeDuc,Vineet D. Menachery,Pei Yong Shi +15 more
TL;DR: The reverse genetic system and reporter virus provide key reagents to study SARS-CoV-2 and develop countermeasures and were successfully used to evaluate the antiviral activities of interferon (IFN).
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