Journal ArticleDOI
New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score.
Anthony W.H. Chan,Ronald C. K. Chan,Grace Lai-Hung Wong,Vincent Wai-Sun Wong,Paul Cheung-Lung Choi,Henry Lik-Yuen Chan,Ka Fai To +6 more
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TLDR
This work aims to investigate the prognostic significance of a new prognostic score, the albumin‐bilirubin (ALBI) score, among PBC patients.Abstract:
Background and Aim
Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin-bilirubin (ALBI) score, among PBC patients.
Methods
In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow-up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well-established prognostic scores: Child–Pugh score, model of end-stage liver disease, Mayo risk score, Yale, European, and Newcastle models.
Results
Fifteen patients (24.6%) developed hepatic events during follow-up. The c-index (0.894) and χ2 by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P −2.60 to −1.39), and grade 3 (> −1.39) groups. The 2-, 5-, and 10-year event-free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P < 0.001).
Conclusion
The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.read more
Citations
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Journal ArticleDOI
Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection.
Anthony W.H. Chan,Jian-Hong Zhong,Sarah Berhane,Hidenori Toyoda,Alessandro Cucchetti,KeQing Shi,Toshifumi Tada,Charing C N Chong,Bang-De Xiang,Le-Qun Li,Paul B.S. Lai,Vincenzo Mazzaferro,Marta García-Fiñana,Masatoshi Kudo,Takashi Kumada,Sasan Roayaie,Philip J. Johnson +16 more
TL;DR: Large international study develops a statistical method that allows clinicians to estimate the risk of recurrence in an individual patient and shows that such models will be valuable in guiding surveillance follow-up and in the design of post-resection adjuvant therapy trials.
Journal ArticleDOI
Integration of albumin–bilirubin (ALBI) score into Barcelona Clinic Liver Cancer (BCLC) system for hepatocellular carcinoma
Anthony W.H. Chan,Takshi Kumada,Hidenori Toyoda,Toshifumi Tada,Charing C N Chong,Frankie Mo,Winnie Yeo,Philip J. Johnson,Paul Bo-San Lai,Anthony T.C. Chan,Ka Fai To,Stephen L. Chan +11 more
TL;DR: The albumin–bilirubin (ALBI) grade is a recently reported, simpler, more objective, and evidence‐based alternative to the Child-Pugh score for hepatocellular carcinoma (HCC).
Journal ArticleDOI
Protons versus Photons for Unresectable Hepatocellular Carcinoma: Liver Decompensation and Overall Survival
Nina N. Sanford,Jennifer Pursley,B. Noe,Beow Y. Yeap,Lipika Goyal,Jeffrey W. Clark,Jill N. Allen,Lawrence S. Blaszkowsky,David P. Ryan,Cristina R. Ferrone,Kenneth K. Tanabe,Motaz Qadan,Christopher H. Crane,Eugene J. Koay,Christine E. Eyler,Thomas F. DeLaney,Andrew X. Zhu,Jennifer Y. Wo,Clemens Grassberger,Theodore S. Hong +19 more
TL;DR: Proton radiation therapy was associated with improved survival, which may be driven by decreased incidence of posttreatment liver decompensation, and the findings support prospective investigations comparing proton versus photon ablative radiation therapy for HCC.
Journal ArticleDOI
Hepatocellular Carcinoma: Nomograms Based on the Albumin-Bilirubin Grade to Assess the Outcomes of Radiofrequency Ablation
Wei Yu Kao,Chien Wei Su,Yi You Chiou,Nai Chi Chiu,Chien An Liu,Kuan Chieh Fang,Teh Ia Huo,Yi Hsiang Huang,Chun Chao Chang,Chun Chao Chang,Ming Chih Hou,Han Chieh Lin,Jaw Ching Wu +12 more
TL;DR: A simple nomogram based on the ALBI grade offers personalized long-term survival data for patients with early-stage HCC who undergo RFA, and results showed that patient age older than 65 years, a prothrombin time international normalized ratio greater than 1.1, α-fetoprotein level greater than 20 ng/mL, multiple tumors, and ALBIgrade 2 or 3 were associated with overall mortality.
Journal ArticleDOI
Albumin-Bilirubin Score: Predicting Short-Term Outcomes Including Bile Leak and Post-hepatectomy Liver Failure Following Hepatic Resection
Nikolaos Andreatos,Neda Amini,Faiz Gani,Georgios A. Margonis,Kazunari Sasaki,Vanessa M. Thompson,David J. Bentrem,Bruce L. Hall,Henry A. Pitt,Ana Wilson,Timothy M. Pawlik,Timothy M. Pawlik +11 more
TL;DR: The ALBI score was associated with short-term post-operative outcomes following hepatic resection and represents a useful pre-operative risk-assessment tool to identify patients at risk for adverse post-operative outcomes.
References
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Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade
Philip J. Johnson,Sarah Berhane,Chiaki Kagebayashi,Shinji Satomura,M Teng,Helen L. Reeves,James O'Beirne,Richard Fox,Anna Skowronska,D. Palmer,Winnie Yeo,Frankie Mo,Paul B.S. Lai,Mercedes Iñarrairaegui,Stephen L. Chan,Bruno Sangro,Rebecca A. Miksad,Toshifumi Tada,Takashi Kumada,Hidenori Toyoda +19 more
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A model to predict survival in patients with end-stage liver disease
Patrick S. Kamath,Russell H. Wiesner,Michael Malinchoc,Walter K. Kremers,Terry M. Therneau,Gennaro D'Amico,Catherine L. Kosberg,E. R. Dickson,W. R. Kim +8 more
TL;DR: The MELD scale is a reliable measure of mortality risk in patients with end-stage liver disease and suitable for use as a disease severity index to determine organ allocation priorities in patient groups with a broader range of disease severity and etiology.
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TL;DR: The clinical care for patients with cholestatic liver diseases has advanced considerably during recent decades thanks to growing insight into pathophysiological mechanisms and remarkable methodological and technical developments in diagnostic procedures as well as therapeutic and preventive approaches.
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