Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.
Homero Rubbo,Rafael Radi,M Trujillo,R. Telleri,Balaraman Kalyanaraman,Stephen Barnes,Marion Kirk,Bruce A. Freeman +7 more
TLDR
In this paper, the influence of NO on membrane lipid peroxidation induced by O2-, H2O2, and OH derived from xanthine oxidase (XO) and by ONOO- was assessed by formation of thiobarbituric acid-reactive products and by liquid chromatography-mass spectrometry.About:
This article is published in Journal of Biological Chemistry.The article was published on 1994-10-21 and is currently open access. It has received 1371 citations till now. The article focuses on the topics: Lipid peroxidation & Lipid oxidation.read more
Citations
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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.
J. S. Beckman,Willem H. Koppenol +1 more
TL;DR: The rapid diffusion of nitric oxide between cells allows it to locally integrate the responses of blood vessels to turbulence, modulate synaptic plasticity in neurons, and control the oscillatory behavior of neuronal networks.
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Mitochondrial formation of reactive oxygen species.
TL;DR: This review describes the main mitochondrial sources of reactive species and the antioxidant defences that evolved to prevent oxidative damage in all the mitochondrial compartments and discusses various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants.
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Role of Oxidative Modifications in Atherosclerosis
Roland Stocker,John F. Keaney +1 more
TL;DR: An "oxidative response to inflammation" model is proposed as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.
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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
TL;DR: This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
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Antioxidants in human health and disease
TL;DR: Experimental approaches to the optimization of antioxidant nutrient intake are proposed, and interest is also growing in the role of plant phenolics, especially flavonoids.
References
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Nitric oxide: physiology, pathophysiology, and pharmacology
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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TL;DR: It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
TL;DR: It is proposed that superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathological conditions by preventing the formation of peroxynitrite.
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Nitric oxide as a secretory product of mammalian cells.
TL;DR: How different forms of nitric oxide synthase help confer specificity and diversity on the effects of this remarkable signaling molecule is reviewed.
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Nitric oxide: an endogenous modulator of leukocyte adhesion.
P Kubes,M Suzuki,D. N. Granger +2 more
TL;DR: Data suggest that endothelium-derived NO may be an important endogenous modulator of leukocyte adherence and that impairment of NO production results in a pattern ofLeukocyte adhesion and emigration that is characteristic of acute inflammation.